GeneTex
United States (US)

GDF8 / Myostatin recombinant protein

Cat No. GTX65102

Application ELISA, Functional Assay, Apuri, Blocking
Reactivity Human
Species Human
APPLICATION

Application Note

Protein's bioactivity determined by its ability to inhibit the proliferation of MPC-11 cells. The ED50 for this effect is <20 ng/ml.

Calculated MW

24.8 kDa. ( Note )
PROPERTIES

Form

Lyophilized powder

Storage

It is recommended to reconstitute the lyophilized human Myostatin in sterile 20 mM acetic acid to a concentration of 0.1 to 1.0 mg/ml. This solution can then be diluted into other aqueous buffers. Store at -20ºC.

Antigen Species

Human

Expression System

E. coli

Purification


Purity was assessed by SDS-PAGE (≥98%) and by HPLC (≥98%).

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

Growth Differentiation Factor8, GDF-8, GDF8, MSTN, MSTN Muscle Hypertrophy, Growth Differentiation Factor 8, GDF 8

Background

Myostatin, also known as Growth Differentiation Factor-8 (GDF-8), belongs to the TGF-beta superfamily. Along with other members of the TGF-beta family, Myostatin plays a crucial role as a regulator for embryonic development and tissue homeostasis in adult animals. Early studies show that Myostatin has the ability to halt muscle growth. New research has further suggested that Myostatin may also be involved in reducing and preventing adiposity and type-2 diabetes. Human Myostatin is a homodimeric protein with each subunit containing 109 amino acid residues with a total molecular weight of 24.8 kDa.

Research Area

Package List Price ($)
$ 249