Reconstitute to 1 mg/ml with sterilized ddH2O. Store at -20ºC.
Purity was assessed by SDS-PAGE (≥95%) and by HPLC (≥95%).
For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Gremlin (also known as Increased in High Glucose Protein 2, IHG-2, Down-regulated in Mos-transformed cells protein, Drm) functions as a bone morphogenetic protein (BMP) antagonist. It acts by binding to, and forming heterodimers with BMP-2, BMP-4, BMP-7, thus preventing them from interacting with their cell surface receptors. Recombinant human Gremlin-2 is a N-terminus His-tagged protein that was expressed from E. coli.