GeneTex
United States (US)

Growth hormone Receptor (Active) recombinant protein

Cat No. GTX65106

Application ELISA, Functional Assay, Apuri, Blocking
Reactivity Human
Species Human
APPLICATION

Application Note

GHBP is fully biologically active as evidenced by its ability of forming 2:1 complex with HGH.

Calculated MW

28.1 kDa. ( Note )
PROPERTIES

Form

Lyophilized powder

Buffer

0.0045 mM NaHCO3

Storage

Reconstitute in sterile ddH2O. Store at -80ºC. Product is stable for at least 12 months.

Antigen Species

Human

Expression System

E. coli

Purification


Purity was assessed by SDS-PAGE (≥98%) and by HPLC (≥98%).

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

GHBP, GHR, Somatotropin receptor, GH receptor

Background

GHBP is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and interCellular signal transduction pathway leading to growth. A common alternate allele of this gene, called GHRd3, lacks exon three and has been well-characterized. Mutations in this gene have been associated with Laron syndrome, also known as the growth hormone insensitivity syndrome (GHIS), a disorder characterized by short stature. Human Recombinant GHBP expressed from E. coli is a single, non-glycosylated, polypeptide chain containing 237 amino acids and having a molecular mass of 28.1 kDa. GHBP is purified by proprietary chromatographic techniques.

Research Area

Package List Price ($)
$ 379