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Human ICAM1 / CD54 protein, mutant human IgG1 Fc tag (active)

Cat. No. GTX65749-pro

Application

 Functional Assay

Species

 Human
Package
100 μg ($429)
See all ICAM1 / CD54 protein products
PRODUCT

Summary

Non-lytic: Acts as a long lasting fusion protein which only binds to the receptor. Mutations to the complement (C1q) and FcgR I binding sites of the IgGs Fc fragment render the fusion proteins incapable of antibody directed cytotoxicity (ADCC) and complement directed cytotoxicity (CDC).

APPLICATION

Application Note

Shows the biological function of the CD54 moiety and exerts a prolonged circulating half-life caused by the modified Fc domain.

PROPERTIES

Form

Lyophilized powder

Buffer

Reconstitute with 0.2μm-filtered PBS to 100 μg/ml. Lyophilized from 0.2μm-filtered PBS.

Preservative

No preservative

Storage

Store at -20ºC or below. After reconstitution, keep as concentrated solution. Aliquot and avoid freeze-thaw cycles.

Region/Sequence

The extracellular domain of human CD54 [ICAM-1] (a.a. 28-480) is fused to the N-terminus of the Fc region of a mutant human IgG1.

Expression System

CHO cells

Purity

≥ 98% by SDS-PAGE.

Endotoxin

< 0.06 EU/μg

Conjugation

Unconjugated

Note

For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

intercellular adhesion molecule 1 , BB2 , CD54 , P3.58

Database

  • Gene ID: 3383 ICAM1

Research Area

REFERENCE

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REVIEW

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SDS
PBS.pdf
Package List Price ($)
$ 429