GeneTex
United States (US)

Human IL12B / IL12 p40 protein

Cat No. GTX29993-pro

Species Human
PRODUCT

Product Description

Interleukin-12 p40 His Human Recombinant produced in E.Coli is single, a non-glycosylated, polypeptide chain containing 306 amino acids fragment (23-328) with an amino-terminal hexahistidine tag.
APPLICATION

Calculated MW

37.17 kDa. ( Note )
PROPERTIES

Form

Liquid

Buffer

1xPBS, 50% Glycerol.

Storage

Store as concentrated solution. Aliquot and store at -20ºC or below. Avoid freeze-thaw cycles.

Concentration

.0746 mg/ml (Please refer to the vial label for the specific concentration.)

Region/Sequence

N-terminus His-Tag

Expression System

E. coli

Purity

> 95% by SDS-PAGE and HPLC.

Endotoxin

< 1 EU/μg

Conjugation

Unconjugated

Note

For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

interleukin 12B , CLMF , CLMF2 , IL-12B , IMD28 , IMD29 , NKSF , NKSF2

Background

This gene encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. This cytokine is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children. [provided by RefSeq, Jul 2008]

Database

Research Area

Package List Price ($)
$ 299