GeneTex
United States (US)

ICAM1 / CD54 antibody [P1W16]

Cat No. GTX40144

Host Mouse
Clonality Monoclonal
Clone Name P1W16
Isotype IgG1
Application ICC/IF, IHC-P, FACS, IP
Reactivity Human
APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
ICC/IF Assay dependent
IHC-P Assay dependent
FACS Assay dependent
IP Assay dependent
Not tested in other applications.

Calculated MW

58 kDa kDa. ( Note )

Positive Control

Positive control lysate: A375M melanoma cell line or tonsil 85-115 kDa MW

Specificity/Sensitivity

P1W16 may be useful for prognosis of malignant melanoma.
PROPERTIES

Form

Liquid

Buffer

Preservative: None. Constituents: PBS

Concentration

0.8mg/ml

Antigen Species

Human

Immunogen

Cell preparation: V(+)B2- Human Ocular melanoma line.

Purification

IgG fraction

Conjugation

Unconjugated

Note

For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

Major group rhinovirus receptor, BB2, intercellular adhesion molecule 1, cell surface glycoprotein P3.58, CD54, human rhinovirus receptor, ICAM1, intercellular adhesion molecule1, P3.58

Cellular Localization

Type I membrane protein

Background

ICAM1 is a 85-110 kDa single-chain type 1 integral membrane glycoprotein with an extracellular domain of five immunoglobulin superfamily repeats, a transmembrane region and a cytoplasmic domain. It shares considerable amino acid sequence homology with ICAM3 and with ICAM2. ICAM1 is expressed by activated endothelial cells. It is detected on cells of many other lineages (e.g. epithelial cells, fibroblasts, chondrocytes, B lymphocytes, T lymphocytes (low), monocytes, macrophages, dendritic cells and neutrophils, with lower levels that increase in inflammation. Also, ICAM1 is detected in some carcinoma and melanoma cells. Soluble ICAM1 is detectable in the plasma and is elevated in patients with various inflammatory syndromes. It is the receptor for rhinoviruses and malaria.
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Database

Research Area