GeneTex

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United States (US)

IL12 antibody

Cat. No. GTX20050

Reference 1

Host

 Mouse

Clonality

 Monoclonal

Isotype

 IgG1

Application

 IHC-Fr, ELISA, RIA

Reactivity

 Human
Package
100 μg ($339)
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APPLICATION

Application Note

For ELISA: Use at an assay dependent concentration. For RIA: Use at an assay dependent concentration. Optimal dilutions/concentrations should be determined by the end user.

Product Note

Recognises p35/40 heterodimer and p40. Used against CCHO and Baculovirus derived recombinant IL-12. Reacts with stimulated and unstimulated monocytes.

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

No preservative

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.7 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Recombinant human interleukin-12 produced in Baculovirus.

Purification

Protein A affinity purified

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

Subunit P40 , Natural Killer Cell Stimulatory Factor2 , Natural Killer Cell Stimulatory Factor 2 , Interleukin 12B , 40 kD Subunit , Cytotoxic lymphocyte maturation factor 40 kDa subunit , T cell stimulating factor , Cytotoxic lymphocyte maturation factor40 kDa subunit , CLMF2 , Interleukin12B , TSF , Cytotoxic Lymphocyte Maturation Factor 2 , IL12 , Cytotoxic Lymphocyte Maturation Factor2 , HGNC:5970 , IL1 , NKSF2 , CLMF , IL-12B , NKSF , IL 12B , IL12B

Cellular Localization

Secreted

Background

IL12 is a heterodimeric cytokine comprised of p35 and p40 subunits. IL12 plays a central role in mediating cell mediated immunity, promoting differentiation of CD4+ T cells to the Th1 subset and of CD8+ T cells into mature cytotoxic T lymphocytes (CTLs). IL12 is a potent stimulator of NK cells. IL12 therapy has been suggested as a method of enhancing cytocidal anti tumour immune responses.

Research Area

REFERENCE

Clone Reference

Sindrilaru A et al. J Clin Invest 2011; 121 (3):985-97 An unrestrained proinflammatory * macrophage population induced by iron impairs wound healing in humans and mice.
Application : IHC-Fr
Reactivity : Human
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Package List Price ($)
$ 339
Custom Conjugations