Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1 mg/ml.
Keep as concentrated solution. Store at 4ºC short term. For extended storage aliquot and store at -20ºC or below. Avoid freeze-thaw cycles.
Sterile filtered Greater than 98% pure by SDS-PAGE and HPLC analyses. Endotoxin level is less than 0.1 ng per μg (1EU/μg).
For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
IL16, also known as lymphocyte chemoattractant factor (LCF), is a proinflammatory cytokine that is chemotactic for CD4+ T lymphocytes, monocytes, and eosinophils. It was originally identified as a CD8+ T cell derived chemoattractant for CD4+ cells. The biologically active form of IL16, originally proposed to be a homotetramer of 14 kDa chains with 130 amino acid residues, is now believed to have been derived from the C terminus of the precursor molecule. Subsequently, IL16 is synthesized as a precursor molecule (pro IL16) of approximately 68 kDa and 631 amino acid residues lacking a signal peptide. The sequence and structure of IL16 is conserved across species. Structurally and functionally, particularly in the C terminal region, human and mouse IL16 share approximately 82 % similarity.