GeneTex
United States (US)

IL6 antibody [IL6/1270]

GTX34795_20170712_IHC-P_1_18121410_775.jpg
GTX34795_20170712_IHC-P_18121410_963.jpg

Cat No. GTX34795

Host Rat
Clonality Monoclonal
Clone Name IL6/1270
Isotype IgG1
Application IHC-P
Reactivity Human, Mouse
APPLICATION

Application Note

IHC-P:1-2ug/ml for 30 minutes at RT.

Calculated MW

24 kDa. ( Note )

Specificity/Sensitivity

IL-6 is a potent lymphoid cell growth factor that stimulates the growth and survivability of certain B-cells and T-cells. It plays a critical role in B-cell differentiation to plasma cells and is a potent growth factor for plasmacytoma and myeloma. IL-6 is produced by a variety of cell types, including monocytes, fibroblasts and endothelial cells. Upon stimulation, macrophages, T, B, mast, and glial cells, eosinophils, keratinocytes and granulocytes also secrete IL-6. It is involved in host defense, acute phase reactions, immune responses, and hematopoiesis.
PROPERTIES

Form

Liquid

Buffer

Prepared in 10mM PBS with 0.05% BSA and 0.05% azide.

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Immunogen

Recombinant IL-6 protein

Purification

Ab purified from Bioreactor Concentrate by Protein A/G

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

Interleukin 6,Bsf-2,Bsf2,Cdf,Hgf,Hsf,Ifn-Beta-2,Ifnb2,Il-6,Il6

Background

This gene encodes a cytokine that functions in inflammation and the maturation of B cells. In addition, the encoded protein has been shown to be an endogenous pyrogen capable of inducing fever in people with autoimmune diseases or infections. The protein is primarily produced at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of this gene is implicated in a wide variety of inflammation-associated disease states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis. [provided by RefSeq, Jun 2011]

Database

Research Area

DATA IMAGES
GTX34795_20170712_IHC-P_1_18121410_775.jpg

GTX34795 IHC-P Image

Formalin-fixed, paraffin-embedded human Colon Carcinoma stained with IL-6 Monoclonal Antibody (IL6/1270).

GTX34795_20170712_IHC-P_18121410_963.jpg

GTX34795 IHC-P Image

Formalin-fixed, paraffin-embedded human Esophageal Carcinoma stained with IL-6 Monoclonal Antibody (IL6/1270).

Package List Price ($)
$ 329