Form
Liquid
Buffer
PBS
Preservative
0.02% Sodium azide
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration
Batch dependent (Please refer to the vial label for the specific concentration.)
Antigen Species
Human
Immunogen
Immunogen Sequence: GI # 5031873, sequence 270-470 Recombinant lectin, mannose-binding, 1
Purification
Purified by affinity chromatography
Conjugation
Unconjugated
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
Synonyms
lectin, mannose binding 1 , ERGIC-53 , ERGIC53 , F5F8D , FMFD1 , MCFD1 , MR60 , gp58
Background
Mannose-specific lectin. May recognize sugar residues of glycoproteins. glycolipids. or glycosylphosphatidyl inositol anchors and may be involved in the sorting or recycling of proteins. lipids. or both. The LMAN1-MCFD2 complex forms a specific cargo receptor for the ER-to-Golgi transport of selected proteins.The protein encoded by this gene is a type I integral membrane protein localized in the intermediate region between the endoplasmic reticulum and the Golgi. presumably recycling between the two compartments. The protein is a mannose-specific lectin and is a member of a novel family of plant lectin homologs in the secretory pathway of animal cells. Mutations in the gene are associated with a coagulation defect. Using positional cloning. the gene was identified as the disease gene leading to combined factor V-factor VIII deficiency. a rare. autosomal recessive disorder in which both coagulation factors V and VIII are diminished.
Database
Research Area