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MC1 Receptor antibody

Anti-MC1 Receptor antibody used in Western Blot (WB). GTX03405
Anti-MC1 Receptor antibody used in IHC (Paraffin sections) (IHC-P). GTX03405
Anti-MC1 Receptor antibody used in Western Blot (WB). GTX03405
Anti-MC1 Receptor antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX03405

Cat. No. GTX03405

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, ICC/IF, IHC-P

Reactivity

 Human, Rat
Package
50 μl ($619)
See all MC1 Receptor products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB Assay dependent
ICC/IF Assay dependent
IHC-P Assay dependent
Not tested in other applications.

Calculated MW

35 kDa. ( Note )

Product Note

We do not recommend use of this product for Mouse samples.

PROPERTIES

Form

Liquid

Buffer

PBS pH 7.4, 1% BSA

Preservative

0.05% sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.6 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Peptide (C)HAQGIARLHKRQRPVH, corresponding to amino acid residues 217-232 of human MC1R (3rd intracellular loop).

Purification

Purified by antigen-affinity chromatography

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

melanocortin 1 receptor , CMM5 , MSH-R , SHEP2

Cellular Localization

Cell membrane; Multi-pass membrane protein

Background

This intronless gene encodes the receptor protein for melanocyte-stimulating hormone (MSH). The encoded protein, a seven pass transmembrane G protein coupled receptor, controls melanogenesis. Two types of melanin exist: red pheomelanin and black eumelanin. Gene mutations that lead to a loss in function are associated with increased pheomelanin production, which leads to lighter skin and hair color. Eumelanin is photoprotective but pheomelanin may contribute to UV-induced skin damage by generating free radicals upon UV radiation. Binding of MSH to its receptor activates the receptor and stimulates eumelanin synthesis. This receptor is a major determining factor in sun sensitivity and is a genetic risk factor for melanoma and non-melanoma skin cancer. Over 30 variant alleles have been identified which correlate with skin and hair color, providing evidence that this gene is an important component in determining normal human pigment variation. [provided by RefSeq, Jul 2008]

Database

Research Area

DATA IMAGES

Anti-MC1 Receptor antibody used in Western Blot (WB). GTX03405

GTX03405 WB Image

WB analysis of rat adrenal tissue lysates using GTX03405 MC1 Receptor antibody.
Lane 1 : Primary antibody
Lane 2 : Primary antibody preincubated with MC1 Receptor Blocking Peptide
Dilution : 1:400

Anti-MC1 Receptor antibody used in IHC (Paraffin sections) (IHC-P). GTX03405

GTX03405 IHC-P Image

IHC-P analysis of normal skin and melanoma tissue using GTX03405 MC1 Receptor antibody. MCR1 staining red-brown color is highly specific in A. epidermal cells, B. eccrine sweat gland cells and C. melanoma cells.
Dilution : 1:100

Anti-MC1 Receptor antibody used in Western Blot (WB). GTX03405

GTX03405 WB Image

WB analysis of Malme-3 (lanes 1 and 4), Malme-3M (lanes 2 and 5), and A875 (lanes 3 and 6) cell lysates using GTX03405 MC1 Receptor antibody.
Lane 1-3 : Primary antibody
Lane 4-6 : Primary antibody preincubated with MC1 Receptor Blocking Peptide
Dilution : 1:500

Anti-MC1 Receptor antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX03405

GTX03405 ICC/IF Image

ICC/IF analysis of PFA-fixed Malme-3M cells using GTX03405 MC1 Receptor antibody.
Dilution : 1:200

REFERENCE

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REVIEW

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Package List Price ($)
$ 619