APPLICATION
Application Note
*Optimal dilutions/concentrations should be determined by the researcher.
| Application |
Recommended Dilution |
| 2.5 - 5 μg/ml |
Not tested in other applications.
Calculated MW
Predict Reactivity
Cat, Baboon, Chimpanzee, Gibbon, Gorilla, Orangutan, Panda(>80% identity)
PROPERTIES
Form
Liquid
Buffer
PBS
Preservative
0.1% Sodium azide
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration
1 mg/ml (Please refer to the vial label for the specific concentration.)
Antigen Species
Human
Immunogen
Synthetic 16 amino acid peptide from 3rd cytoplasmic domain of human MC1 Receptor.
Purification
Purified by affinity chromatography
Conjugation
Unconjugated
RRID
AB_375543
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
TARGET
Synonyms
melanocortin 1 receptor , CMM5 , MC1R , MSHR , SHEP2 , MC1 Receptor
Cellular Localization
Cell membrane
Background
This intronless gene encodes the receptor protein for melanocyte-stimulating hormone (MSH). The encoded protein, a seven pass transmembrane G protein coupled receptor, controls melanogenesis. Two types of melanin exist: red pheomelanin and black eumelanin. Gene mutations that lead to a loss in function are associated with increased pheomelanin production, which leads to lighter skin and hair color. Eumelanin is photoprotective but pheomelanin may contribute to UV-induced skin damage by generating free radicals upon UV radiation. Binding of MSH to its receptor activates the receptor and stimulates eumelanin synthesis. This receptor is a major determining factor in sun sensitivity and is a genetic risk factor for melanoma and non-melanoma skin cancer. Over 30 variant alleles have been identified which correlate with skin and hair color, providing evidence that this gene is an important component in determining normal human pigment variation. [provided by RefSeq, Jul 2008]
Database
Research Area
DATA IMAGES
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GTX71097 IHC-P Image
IHC-P analysis of human adrenal tissue using GTX71097 MC1 Receptor antibody.
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GTX71097 IHC-P Image
IHC-P analysis of human kidney tissue using GTX71097 MC1 Receptor antibody.
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REFERENCE
There are currently no references for MC1 Receptor antibody (GTX71097). Be the first to share your publications with this product.
REVIEW
There are currently no reviews for MC1 Receptor antibody (GTX71097). Be the first to share your experience with this product.
