GeneTex
United States (US)

MIP1 alpha protein

Cat No. GTX29674

Reactivity Human
Species Human
APPLICATION

Positive Control

Recombinant hIL-11 (ab
PROPERTIES

Form

Lyophilized powder

Storage

The lyophilized protein is stable for a few weeks at room temperature, but best stored at -20 ºC. We recommend a quick spin followed by reconstitution in water to a concentration of 0.1 mg/ml. This solution can then be diluted into other buffers and

Antigen Species

Human

Region/Sequence

Highly pure (>98%) recombinant hIL-11 (human Interleukin-11)

Purification


Sterile filtered Greater than 98% pure by SDS-PAGE and HPLC analyses. Endotoxin level is less than 0.1 ng per μg (1EU/μg).

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

C-C Motif Chemokine Ligand 3,G0S19-1,Ld78Alpha,Mip-1-Alpha,Mip1A,Scya3,Ccl3

Cellular Localization

Secreted

Background

MIP1 alpha and MIP1 beta, two closely related but distinct proteins, were originally co-purified from medium conditioned by a LPS-stimulated murine macrophage cell line. Mature mouse MIP1 alpha shares approximately 77% and 70% amino acid identity with human MIP1 alpha and mouse MIP1 beta, respectively. MIP1 proteins are expressed primarily in T cells, B cells, and monocytes after antigen or mitogen stimulation. Has adhesive effects on lymphocytes. MIP1 alpha can inhibit the proliferation of hematopoietic stem cells in vitro as well as in vivo. A signal transducing receptor, designated the C-C chemokine receptor-1 (C-C CKR-1) with seven transmembrane domains that bind MIP1 alpha, MIP1 beta, MCP1 and RANTES with varying affinities, has been isolated.

Research Area

Package List Price ($)
$ 299