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MTH1 antibody

Anti-MTH1 antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX30108
Anti-MTH1 antibody used in Western Blot (WB). GTX30108
Anti-MTH1 antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX30108
Anti-MTH1 antibody used in Western Blot (WB). GTX30108

Cat. No. GTX30108

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, ICC/IF, IHC-P, IHC-Fr

Reactivity

 Human, Mouse, Rat, Monkey
Package
200 μl ($449)
See all MTH1 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1:500
ICC/IF 1:50 - 1:200
IHC-P Assay dependent
IHC-Fr 1:200
Not tested in other applications.

Calculated MW

23 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

0.02% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

A C-terminal peptide derived from human MTH1, conjugated to KLH. [UniProt# P36639]

Purification

Purified by antigen-affinity chromatography

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

nudix hydrolase 1 , MTH1

Cellular Localization

Mitochondrion matrix,Nucleus

Background

Misincorporation of oxidized nucleoside triphosphates into DNA/RNA during replication and transcription can cause mutations that may result in carcinogenesis or neurodegeneration. The protein encoded by this gene is an enzyme that hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP, 8-oxo-dATP, 2-hydroxy-dATP, and 2-hydroxy rATP, to monophosphates, thereby preventing misincorporation. The encoded protein is localized mainly in the cytoplasm, with some in the mitochondria, suggesting that it is involved in the sanitization of nucleotide pools both for nuclear and mitochondrial genomes. Several alternatively spliced transcript variants, some of which encode distinct isoforms, have been identified. Additional variants have been observed, but their full-length natures have not been determined. A single-nucleotide polymorphism that results in the production of an additional, longer isoform (p26) has been described. [provided by RefSeq]

Database

Research Area

DATA IMAGES

Anti-MTH1 antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX30108

GTX30108 ICC/IF Image

ICC/IF analysis of HeLa cells using GTX30108 MTH1 antibody.
Green : primary antibody
Blue : Hoechst 33258

Anti-MTH1 antibody used in Western Blot (WB). GTX30108

GTX30108 WB Image

WB analysis of (1) NTERA-2, (2) MCF-7-, (3) A431, and (4) COS-7 cell lysate using GTX30108 MTH1 antibody.

Anti-MTH1 antibody used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX30108

GTX30108 ICC/IF Image

ICC/IF analysis of A431 cells using GTX30108 MTH1 antibody.
Green : primary antibody
Red : Tubulin
Blue : DAPI
Dilution : 1:200
Fixation : 10% formalin
Permibilization : 0.5% Triton-X100

Anti-MTH1 antibody used in Western Blot (WB). GTX30108

GTX30108 WB Image

WB analysis of A431 cell lysate using GTX30108 MTH1 antibody.

REFERENCE

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REVIEW

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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 449