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NLRP7 antibody

Anti-NLRP7 antibody used in Western Blot (WB). GTX85156
Anti-NLRP7 antibody used in IHC (Paraffin sections) (IHC-P). GTX85156
Anti-NLRP7 antibody used in IHC (Paraffin sections) (IHC-P). GTX85156

Cat. No. GTX85156

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, IHC-P, ELISA

Reactivity

 Human
Package
100 μg ($399)
See all NLRP7 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1 μg/mL
IHC-P 10 μg/mL
ELISA Assay dependent
Not tested in other applications.

Calculated MW

112 kDa. ( Note )

Positive Control

Human Brain Tissue Slide(GTX22203) , K562 Cell Lysate(GTX27911)

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

0.02% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

NALP7 antibody was raised against an 18 amino acid synthetic peptide near the amino terminus of human NALP7.The immunogen is located within amino acids 90 - 140 of NALP7.

Purification

Purified by antigen-affinity chromatography

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

NLR family pyrin domain containing 7 , CLR19.4 , HYDM , NALP7 , NOD12 , PAN7 , PYPAF3

Background

NOD proteins include the apoptosis regulator APAF1 (apoptotic protease activating factor 1) and mammalian NOD-LRR proteins. NALP7, also known as PYPAF3, a member of the related PYRIN-containing APAF1-like proteins (PYPAFs/NALPs) is thought to play a crucial role in cell proliferation. NALP7 has a C-terminal leucine-rich repeat (LRR) region, an N-terminal Pyrin domain (PYD) followed by a NACHT domain, and a NACHT-associated domain. It is expressed in numerous tissues including uterus and ovary, with low levels in heart and brain. NALP7 inhibits caspase-1-dependent interleukin-1beta secretion and is a feedback regulator of interleukin-1beta secretion. Defects in the NALP7 gene are known to cause the formation of a hydatidiform mole (HYDM) and reduce the growth of carcinoma cell lines.

Database

Research Area

DATA IMAGES

Anti-NLRP7 antibody used in Western Blot (WB). GTX85156

GTX85156 WB Image

WB analysis of K562 cell lysate in (A) the absence and (B) the presence of blocking peptide using GTX85156 NLRP7 antibody.
Working concentration : 2 μg/ml

Anti-NLRP7 antibody used in IHC (Paraffin sections) (IHC-P). GTX85156

GTX85156 IHC-P Image

IHC-P analysis of human brain tissue using GTX85156 NLRP7 antibody.
Working concentration : 10 μg/ml

Anti-NLRP7 antibody used in IHC (Paraffin sections) (IHC-P). GTX85156

GTX85156 IHC-P Image

IHC-P analysis of human brain tissue using GTX85156 NLRP7 antibody.
Working concentration : 20 μg/ml

REFERENCE

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REVIEW

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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 399