GeneTex
United States (US)

PDGF Receptor alpha antibody (ready-to-use)

PDGFR-alpha-antibody-ready-to-use-GTX15501-IHC-2_18121411_410.jpg
PDGFR-alpha-antibody-ready-to-use_IHC-P_GTX15501-1_18121411_754.jpg

Cat No. GTX15501

Host Rabbit
Clonality Polyclonal
Isotype IgG
Application IHC-P
Reactivity Human, Mouse
APPLICATION

Application Note

IHC-P: Use at an assay dependent dilution. Staining of formalin fixed tissues requires boiling tissue sections in 10mMcitrate buffer, pH 6.0 for 10 min followed by cooling at room temperature for 20 min. Optimal dilutions/concentrations should be determined by the end user.

Calculated MW

123 kDa. ( Note )

Positive Control

Human skin and Ovarian Carcinoma
PROPERTIES

Form

Liquid

Buffer

PBS, pH 7.4 containing 1%BSA and 0.1% sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE.

Concentration

Ready-to-use

Antigen Species

Human

Immunogen

Synthetic peptide (unfortunately, the amino acid sequence is considered to be commercially sensitive) corresponding to C terminal of human PDGFR alpha.

Purification

Immunogen affinity purified

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

Platelet Derived Growth Factor Receptor Alpha,Cd140A,Pdgfr-2,Pdgfr2,Pdgfra

Cellular Localization

Cell Membrane and Cytoplasmic.

Background

Platelet derived growth factor receptor (PDGFR) is a transmembrane glycoprotein of 170-185 kDa which undergoes homo or heterodimerization into complexes of alpha and beta subunits upon ligand binding, depending on the isoform of PDGF (PDGF AA, BB or AB) that binds. The phosphorylation of tyrosine residues in the now activated receptor can control multiple signaling events such as actin reorganization, transcription, cell growth, migration and differentiation, and also lead to activation of the Ras, Raf and ERK 1 and 2 pathway.

Database

Research Area

DATA IMAGES
PDGFR-alpha-antibody-ready-to-use-GTX15501-IHC-2_18121411_410.jpg

GTX15501 IHC-P Image

GTX15501 staining PDGF Receptor alpha in human ovarian carcinoma by Immunohistochemistry (FFPE-sections).

PDGFR-alpha-antibody-ready-to-use_IHC-P_GTX15501-1_18121411_754.jpg

GTX15501 IHC-P Image

Human Ovarian Carcinoma stained with anti-PDGFR alpha antibody (GTX15501)

Package List Price ($)
$ 319