GeneTex
United States (US)

PDGF Receptor beta (Active) recombinant protein

Cat No. GTX65198

Application ELISA, Functional Assay, Apuri, Blocking
Reactivity Human
Species Human
APPLICATION

Application Note

The specific activity of PDGFRb was determined to be 20 nmol /min/mg as per activity assay protocol.

Calculated MW

96.0 kDa. ( Note )
PROPERTIES

Form

Liquid

Buffer

50mM Tris-HCl, pH 7.5, 150mM NaCl, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, 25% glycerol.

Storage

Store at -80ºC. Product is stable for at least 6-12 months.

Concentration

0.1mg/ml(Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Expression System

Baculovirus (Sf9 insect cells)

Purification


Purity was assessed by SDS-PAGE (≥90%) and by HPLC.

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

beta polypeptide, PDGR. plateletderived growth factor receptor, PDGFRB, PDGR. platelet-derived growth factor receptor

Background

PDGFRb (platelet-derived growth factor receptor b) is a member of the PDGFR family of membrane receptors with intrinsic tyrosine kinase activity. PDGFRb deficient mice are hemorrhagic, severely anemic and exhibit a defect in kidney glomeruli function (1). However, absence of PDGFRb has no impact on major blood vessels and the heart. PDGFRb expression and activity is elevated in several cancers and inhibition of PDGFRb activity blocks progression of renal carcinoma in an animal model (2).

Research Area

Package List Price ($)
$ 349