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PTPRB antibody [122.2]

Cat. No. GTX80343

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 122.2

Isotype

 IgM

Application

 WB, ICC/IF, IP

Reactivity

 Rat
Package
50 μl ($399)
See all PTPRB products

APPLICATION

Application Note

Recommended Starting Dilutions:
Use between 1:1000-1:2500
Optimal dilutions should be determined experimentally by the researcher.

Calculated MW

224 kDa. ( Note )

Product Note

PTPRB

PROPERTIES

Form

Liquid

Buffer

Growth Medium (protein free), concentrated and dialysed against PBS

Preservative

No preservative

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Rat

Immunogen

Embryonic rat brain proteoglycans

Purification

Concentrated

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

protein tyrosine phosphatase receptor type B , HPTP-BETA , HPTPB , PTPB , R-PTP-BETA , VEPTP

Cellular Localization

Membrane

Background

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and one intracytoplasmic catalytic domain, thus belongs to receptor type PTP. The extracellular region of this PTP is composed of multiple fibronectin type_III repeats, which was shown to interact with neuronal receptor and cell adhesion molecules, such as contactin and tenascin C. This protein was also found to interact with sodium channels, and thus may regulate sodium channels by altering tyrosine phosphorylation status. The functions of the interaction partners of this protein implicate the roles of this PTP in cell adhesion, neurite growth, and neuronal differentiation. Alternate transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]

Database

Research Area

REFERENCE

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REVIEW

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SDS
PBS.pdf
Package List Price ($)
$ 399