GeneTex
United States (US)

Proinsulin antibody [1D6]

img12636_18121411_827.jpg

Cat No. GTX28299

Host Mouse
Clonality Monoclonal
Clone Name 1D6
Isotype IgG1
Application ELISA, IHC, RIA
Reactivity Human
APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
ELISA Assay dependent
IHC Assay dependent
RIA Assay dependent
Not tested in other applications.

Calculated MW

11.98 kDa. ( Note )

Specificity/Sensitivity

This antibody was generated against the interactions between insulin and C-peptide parts of prohormone. It reacts with different epitopes on human proinsulin molecule from clone 3A1 and 1G4. No cross-reactivity with insulin or C-peptide.
PROPERTIES

Form

Liquid

Buffer

PBS pH 7.4, 0.09 % sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4º C.

Concentration

Batch dependent(Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Purified human proinsulin

Purification

Protein A purified

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

IDDM, IDDM1, IDDM2, ILPR, INS, IRDN, MODY10, insulin, Insulin

Cellular Localization

Secreted

Background

After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010]

Database

Research Area

DATA IMAGES
img12636_18121411_827.jpg

GTX28299 IHC Image


Package List Price ($)
$ 289