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Rb antibody [Rb]

Cat No. GTX20024

Host Mouse
Clonality Monoclonal
Clone Name Rb
Isotype IgG1
Application WB, IHC-Fr, IP, IHC
Reactivity Human, Mouse, Rat, Chimpanzee
Package
100 μg ($319)
APPLICATION

Application Note

IHC-Fr: Use at an assay dependent dilution. IP: Use at an assay dependent dilution. WB: Use at an assay dependent dilution. Predicted molecular weight: 105 kDa. Optimal dilutions/concentrations should be determined by the end user.

Calculated MW

106 kDa. ( Note )

Positive Control

Tested in a panel of human cell lines and CV-1 cell line (established from monkey kidney epithelium)
PROPERTIES

Form

Liquid

Buffer

Phosphate-buffered saline

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1.1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

The immunogen corresponding to a region within amino acids 703 and 772 of human RB1.

Purification

Protein A purified

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

Rb Transcriptional Corepressor 1,Osrc,Ppp1R130,Rb,P105-Rb,Prb,Pp110,Rb1

Cellular Localization

Nuclear

Background

The Retinoblastoma (Rb) protein is an abundant molecule in the nucleus of mammalian cells and is continuously present in cells regardless of whether the cell is in the G0 (growth factor absent) or proliferating stage of the cell cycle. It is the product of the Rb susceptibility gene; the protein itself is a negative regulator, controlling the passage of cells from G1 to S phase of the cell cycle. The action of the Rb protein is controlled by phosphorylation.

Database

Research Area

REFERENCE
REVIEW
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Package List Price ($)
$ 319