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SIPA1L1 antibody

Anti-SIPA1L1 antibody used in IHC (Paraffin sections) (IHC-P). GTX85228
Anti-SIPA1L1 antibody used in Western Blot (WB). GTX85228
Anti-SIPA1L1 antibody used in IHC (Paraffin sections) (IHC-P). GTX85228

Cat. No. GTX85228

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, IHC-P, ELISA

Reactivity

 Human, Mouse, Rat
Package
100 μg ($399)
See all SIPA1L1 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 0.5 - 1 μg/mL
IHC-P 5 μg/mL
ELISA Assay dependent
Not tested in other applications.

Calculated MW

200 kDa. ( Note )

Positive Control

Human Brain Tissue Slide(GTX22203) , Rat Brain Tissue Lysate(GTX27942)

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

0.02% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

SIPA1L1 antibody was raised against a 16 amino acid synthetic peptide from near the amino terminus of human SIPA1L1.The immunogen is located within amino acids 40 - 90 of SIPA1L1.

Purification

Purified by antigen-affinity chromatography

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

signal induced proliferation associated 1 like 1 , E6TP1

Cellular Localization

Cytoplasm, cytoskeleton

Background

Signal-induced proliferation associated-like protein 1 (SIPA1L1) is a member of the SIPA1 family of RapGAPs. SIPA1L1 was initially identified as a binding partner and degradation target of the E6 oncoprotein of high-risk papillomaviruses. Recently, it was discovered that Casein kinase I epsilon (CKIe), a Wnt-regulated kinase that regulates Wnt/b-catenin signaling, also can bind to the carboxy-terminus of SIPA1L1. CKIe phosphorylates SIPA1L1, thereby reducing its stability and alleviating its inhibition of Rap1, a protein required for Wnt8/CKIe-mediated gastrulation during embryogenesis, suggesting SIPA1L1 plays important roles in embryo development as well as control of cell proliferation.

Database

Research Area

DATA IMAGES

Anti-SIPA1L1 antibody used in IHC (Paraffin sections) (IHC-P). GTX85228

GTX85228 IHC-P Image

IHC-P analysis of human brain tissue using GTX85228 SIPA1L1 antibody.
Working concentration : 5 μg/ml

Anti-SIPA1L1 antibody used in Western Blot (WB). GTX85228

GTX85228 WB Image

WB analysis of rat brain tissue lysate using GTX85228 SIPA1L1 antibody.
Working concentration : (A) 0.5 and (B) 1 μg/ml

Anti-SIPA1L1 antibody used in IHC (Paraffin sections) (IHC-P). GTX85228

GTX85228 IHC-P Image

IHC-P analysis of human brain tissue using GTX85228 SIPA1L1 antibody.
Working concentration : 20 μg/ml

REFERENCE

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REVIEW

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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 399