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Sialosyl-Tn antigen antibody [STn 219]

Cat. No. GTX82967

Reference 1

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 STn 219

Isotype

 IgG1

Application

 ICC/IF, IHC-P, IHC

Reactivity

 Human
Package
500 μl ($399)
See all Sialosyl-Tn antigen products

APPLICATION

Application Note

IHC, ICC (frozen or formalin–fixed paraffin-embedded (FFPE) tissue sections, cell smears. For IHC dilute conc. antibodies 1:50-1:100, use streptavidin~biotin system or polymer system, incubate 30 minutes at room temperature.

Positive Control

Human gastrointestinal tumor, prostate, ovary ca.

PROPERTIES

Form

Liquid

Buffer

PBS, pH7.2 1% BSA

Preservative

0.05% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE.

Concentration

0.20 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Ovine submaxillary mucin (OSM)

Purification

Affinity purified by Protein A.

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

CD175s antibody , Sialosyl Tn antibodys , Tn antibody

Cellular Localization

Cytoplasmic, apical membrane, luminal

Background

Sialyl-Tn is a carbohydrate antigen overexpressed in several epithelial cancers including breast cancer, and usually associated with poor prognosis. Sialyl-Tn is synthesized by a CMP-Neu5Ac: GalNAc alpha2,6-sialyltransferase: ST6GalNAc I, which catalyzes the transfer of a sialic acid residue in alpha2,6-linkage to the GalNAcalpha1-O-Ser/Thr structure. The resulting disaccharide (Neu5Acalpha2-6GalNAcalpha1-O-Ser/Thr) cannot be further elongated and sialyl-Tn expression results therefore in a shortening of the O-glycan chains

Research Area

REFERENCE

Application Reference

LJ Kuo et al. Asian J Surg 2023; Tn as a potential predictor for regional lymph node metastasis in T1 colorectal cancer
Application : IHC-P
Reactivity : Human
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REVIEW

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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 399