GeneTex
United States (US)

TGF alpha antibody [134A-2B3]

Cat No. GTX16858

Host Mouse
Clonality Monoclonal
Clone Name 134A-2B3
Isotype IgG1
Application WB
Reactivity Human, Rat
APPLICATION

Application Note

For WB: Use at a dilution of 1-5 μg/ml. Predicted molecular weight: 17 kDa or 6 kDa (mature form). Optimal dilutions/concentrations should be determined by the researcher.

Calculated MW

17 kDa. ( Note )

Positive Control

A2058 or ST-FeSV FRE cells
PROPERTIES

Form

Liquid

Buffer

50 mM sodium phosphate buffer, 0.2% gelatin with =0.1% sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE.

Concentration

0.1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Recombinant full length protein (Human).

Purification

Purified IgG

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

Transforming Growth Factor Alpha,Tfga,Tgfa

Cellular Localization

Type I membrane protein (precursor form) and extracellular (mature form).

Background

Transforming growth factor-alpha (TGF alpha) is an acid- and heat-stable originally discovered in rodents and humans. TGF alpha protien is 33% homologous to epidermal growth factor (EGF). TGF alpha binds to the EGF receptor, mediating tyrosine phosphorylation of the receptor, and promotes anchorage-independent growth of normal rat fibroblasts in soft agar in the presence of transforming growth factor-beta. TGF alpha is secreted by a variety of transformed cells and tumors, embryonic cells and some normal adult cells . TGF alpha bioactivity has also been found in the urine of cancer patients. It has been suggested that it may act as an autocrine growth factor for the induction or maintenance of malignancy.

Database

Research Area