GeneTex
United States (US)

TIGAR recombinant protein

Cat No. GTX53860

Species Human
APPLICATION

Calculated MW

29.9 kDa. ( Note )
PROPERTIES

Form

Lyophilized powder

Storage

Keep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Antigen Species

Human

Expression System

E. Coli

Purity

Above 95% as determined by SDS-PAGE Analysis.

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

Tp53 Induced Glycolysis Regulatory Phosphatase,C12Orf5,Fr2Bp,Tigar

Background

This gene is regulated as part of the p53 tumor suppressor pathway and encodes a protein with sequence similarity to the bisphosphate domain of the glycolytic enzyme that degrades fructose-2,6-bisphosphate. The protein functions by blocking glycolysis and directing the pathway into the pentose phosphate shunt. Expression of this protein also protects cells from DNA damaging reactive oxygen species and provides some protection from DNA damage-induced apoptosis. The 12p13.32 region that includes this gene is paralogous to the 11q13.3 region. [provided by RefSeq, Jul 2008]

Research Area