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TLR2 antibody

Anti-TLR2 antibody used in Immunohistochemistry (IHC). GTX21655

Cat. No. GTX21655

Reference 1

Host

 Goat

Clonality

 Polyclonal

Isotype

 IgG

Application

 ELISA, IHC

Reactivity

 Human, Mouse
Package
100 μg ($399)
See all TLR2 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
ELISA 1:37,500
IHC 1:125
Not tested in other applications.

Calculated MW

90 kDa. ( Note )

Product Note

Peptide sequence is < 50 % identical to other human TLR receptors in this region.

PROPERTIES

Form

Liquid

Buffer

10mM KHPO₄, 140mM NaCl, 0.1% BSA

Preservative

0.1% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Synthetic peptide C-LEIDASDLQSYEPKSLKSIQNVSHLI corresponding to amino acids 179-204 of human TLR2

Purification

Purified by affinity chromatography

Conjugation

Unconjugated

RRID

AB_372163

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

CD282,TIL4,TLR2,toll like receptor 2

Cellular Localization

Membrane,Cytoplasmic vesicle,Phagosome membrane,Membrane raft

Background

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. This protein is a cell-surface protein that can form heterodimers with other TLR family members to recognize conserved molecules derived from microorganisms known as pathogen-associated molecular patterns (PAMPs). Activation of TLRs by PAMPs leads to an up-regulation of signaling pathways to modulate the host's inflammatory response. This gene is also thought to promote apoptosis in response to bacterial lipoproteins. This gene has been implicated in the pathogenesis of several autoimmune diseases. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

Database

Research Area

DATA IMAGES

Anti-TLR2 antibody used in Immunohistochemistry (IHC). GTX21655

GTX21655 IHC Image

IHC analysis of human spleen tissue using GTX21655 TLR2 antibody.

REFERENCE

Application Reference

Hayati AR et al. Malays J Pathol 2010; 32 (1) : 43356 An immunohistochemical study of Toll-like receptors 2 and 4 in placenta with and without infection.
Application : IHC
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Package List Price ($)
$ 399