APPLICATION
Application Note
*Optimal dilutions/concentrations should be determined by the researcher.
| Application |
Recommended Dilution |
| 1 μg/mL |
| 10 μg/mL |
| Assay dependent |
Not tested in other applications.
Calculated MW
Positive Control
Daudi Cell Lysate(GTX23951) , Jurkat Cell Slide(GTX25533)
Product Note
This TLR6 antibody is predicted to have no cross-reactivity to other members of the TLR protein family.
PROPERTIES
Form
Liquid
Buffer
PBS
Preservative
0.02% Sodium azide
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration
1 mg/ml (Please refer to the vial label for the specific concentration.)
Antigen Species
Human
Immunogen
TLR6 antibody was raised against a peptide corresponding to 15 amino acids near the amino terminus of human TLR6.The immunogen is located within amino acids 160 - 210 of TLR6.
Purification
Purified by antigen-affinity chromatography
Conjugation
Unconjugated
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
TARGET
Synonyms
toll like receptor 6 , CD286
Cellular Localization
Cell membrane,Golgi apparatus
Background
Toll-like receptors (TLRs) are evolutionarily conserved pattern-recognition molecules resembling the toll proteins that mediate antimicrobial responses in Drosophila. These proteins recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses (1,2). The TLRs act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors (3) so the organism can respond to potential infection. TLR6 was first identified as a close homolog of TLR1, sharing 69% sequence identify (4). Like TLR1, TLR6 can form heterodimers with TLR2, and these TLR6:TLR2 dimers coordinate macrophage activation by Gram-positive bacteria and the yeast cell wall particle zymosan (5). Activation of these complexes not only initiates pro-inflammatory cascades, but also can lead to apoptotic responses (6).
Database
Research Area
DATA IMAGES
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GTX85075 WB Image
WB analysis of Daudi cell lysate in (A) the absence and (B) the presence of blocking peptide using GTX85075 TLR6 antibody.
Working concentration : 1 μg/ml
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GTX85075 ICC/IF Image
ICC/IF analysis of Jurkat cells using GTX85075 TLR6 antibody.
Working concentration : 10 μg/ml
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REFERENCE
There are currently no references for TLR6 antibody (GTX85075). Be the first to share your publications with this product.
REVIEW
There are currently no reviews for TLR6 antibody (GTX85075). Be the first to share your experience with this product.
