TMEM38A antibody

Cat. No. GTX85221

Host	Rabbit
Clonality	Polyclonal
Isotype	IgG
Application	WB, IHC-P, ELISA
Reactivity	Human, Mouse, Rat
Package	100 μg ($399)

See all TMEM38A products

Datasheet
Document

View product citations for antibody GTX85221 on CiteAb

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.

Application	Recommended Dilution
WB	1 μg/mL
IHC-P	20 μg/mL
ELISA	Assay dependent

Not tested in other applications.

Calculated MW

33 kDa. ( Note )

Positive Control

Rat Skeletal Muscle Tissue Lysate(GTX27946)

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

0.02% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

TMEM38A antibody was raised against a 17 amino acid synthetic peptide from near the carboxy terminus of human TMEM38A.The immunogen is located within the last 50 amino acids of TMEM38A.

Purification

Purified by antigen-affinity chromatography

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

transmembrane protein 38A , TRIC-A , TRICA

Background

TMEM38A and TMEM38B are two recently identified trimeric intracellular cation (TRIC) channel subtypes. TMEM38A is preferentially expressed in excitable tissues such as striated muscle and brain and localizes to the sarcoplasmic reticulum (SR) in muscle tissues. Mice deficient in both TMEM38A and TMEM38B suffer embryonic cardiac failure; the cardiac myocytes display severe dysfunction in SR Ca2+ handling, weakened Ca2+ release, and reduced K+ permeability indicating that the TRIC cation channels are likely to act as counter-ion channels that function in synchronization with Ca2+ release from intracellular stores. Other experiments have shown that TMEM38A and TMEM38B can act with junctophilin proteins to support efficient ryanodine receptor-mediated Ca2+ release in muscle cells.

Database

Gene ID: 79041 TMEM38A
UniProt: Q9H6F2 TMEM38A

Research Area

DATA IMAGES

GTX85221 WB Image

WB analysis of rat skeletal muscle tissue lysate in (A) the absence and (B) the presence of blocking peptide using GTX85221 TMEM38A antibody.
Working concentration : 1 μg/ml

GTX85221 IHC-P Image

IHC-P analysis of mouse skeletal muscle tissue using GTX85221 TMEM38A antibody.
Working concentration : 20 μg/ml

REFERENCE

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SDS
PBS.pdf
Sodium Azide.pdf

Package

List Price ($)

100 μg

$ 399

Qty