GeneTex
United States (US)

TNFRSF14 antibody [Laury-1]

Cat No. GTX16093

Host Rat
Clonality Monoclonal
Clone Name Laury-1
Isotype IgG2a
Application FACS, IP
Reactivity Human
APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
FACS 1:1,000
IP 1:200

Note :

FACS
HEK 293T cells (5 x 10?) were mock transfected or transfected with HVEM.

Not tested in other applications.

Calculated MW

30 kDa. ( Note )
PROPERTIES

Form

Liquid

Buffer

PBS with 0.02% sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Fusion protein, corresponding to amino acids 39 - 200 (the extracellular domain) of Human TNFRSF14 fused to the Fc portion of human IgG1.

Purification

Purified IgG2a

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

Tnf Receptor Superfamily Member 14,Atar,Cd270,Hvea,Hvem,Lightr,Tr2,Tnfrsf14

Cellular Localization

Type II membrane protein and secreted (isoform 1); Cytoplasmic (isoform 2)

Background

TNFRSF14, also known as HVEM (herpes virus entry mediator), TR2 (TNF receptor like molecule) and ATAR (another TRAF-associated receptor), is a type I membrane protein belonging to the TNF receptor superfamily. This receptor mediates herpes virus entry into cells during infection. TNFRSF14 is able to inhibit the proliferation, activation, and cytokine production of T cells. It has an extracellular domain containing several cysteine-rich repeats and a short cytoplasmic region containing a TRAF (TNF receptor-associated factor) interaction domain. The extracellular domain of TNFRSF14 interacts with the herpes simplex virus envelope glycoprotein D. TNFRSF14 binds two cellular ligands: lymphotoxin alpha and LIGHT. LIGHT is an acronym, which stands for is homologous to lymphotoxins, exhibits inducible expression, and competes with HSV glycoprotein D for HVEM, a receptor expressed by T lymphocytes. The LIGHT:TNFRSF14 interaction controls immune response functions by cell death induction as well as cell activation. TNFRSF14 is expressed by peripheral blood T cells, B cells, monocytes and in various tissues enriched in lymphoid cells.

Database

Research Area

Package List Price ($)
$ 329