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TREX2 antibody

Anti-TREX2 antibody used in Western Blot (WB). GTX85021
Anti-TREX2 antibody used in IHC (Paraffin sections) (IHC-P). GTX85021
Anti-TREX2 antibody used in IHC (Paraffin sections) (IHC-P). GTX85021

Cat. No. GTX85021

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, IHC-P, ELISA

Reactivity

 Human, Mouse, Rat
Package
100 μg ($399)
See all TREX2 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 2.5 μg/mL
IHC-P 2.5 μg/mL
ELISA Assay dependent
Not tested in other applications.

Calculated MW

31 kDa. ( Note )

Positive Control

Rat Liver Tissue Lysate(GTX27943) , Human Liver Tissue Slide

Product Note

This TREX2 antibody will not cross-react with the related protein TREX1.

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

0.02% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

TREX2 antibody was raised against a 15 amino acid synthetic peptide near the carboxy terminus of human TREX2.The immunogen is located within the last 50 amino acids of TREX2.

Purification

Purified by antigen-affinity chromatography

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

three prime repair exonuclease 2

Cellular Localization

Nucleus

Background

TREX2 is one of two major human 3' to 5' exonucleases which are required for checkpoint signaling after DNA damage. While the related protein TREX1 is required for ATR expression and mutations in this gene result in Aicardi-Goutieres syndrome, chilblain lupus, and Cree encephalitis, less is known about TREX2. Like TREX1, TREX2 is ubiquitously expressed in all tissues examined. X-ray crystallography studies of TREX2-single strand DNA complexes revealed that TREX2 binds DNA as a dimer and may act to displace the second DNA strand, suggesting that TREX2 unzips and denatures double stranded DNA and feed the substrate DNA strand into the TREX2 active site. At least two isoforms of TREX2 are known to exist. This TREX2 antibody will not cross-react with the related protein TREX1.

Database

Research Area

DATA IMAGES

Anti-TREX2 antibody used in Western Blot (WB). GTX85021

GTX85021 WB Image

WB analysis of rat liver tissue lysate using GTX85021 TREX2 antibody.
Working concentration : 2.5 μg/ml

Anti-TREX2 antibody used in IHC (Paraffin sections) (IHC-P). GTX85021

GTX85021 IHC-P Image

IHC-P analysis of human liver tissue using GTX85021 TREX2 antibody.
Working concentration : 20 μg/ml

Anti-TREX2 antibody used in IHC (Paraffin sections) (IHC-P). GTX85021

GTX85021 IHC-P Image

IHC-P analysis of human liver tissue using GTX85021 TREX2 antibody.
Working concentration : 2.5 μg/ml

REFERENCE

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REVIEW

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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 399