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TRPC1 antibody

Anti-TRPC1 antibody used in Western Blot (WB). GTX54859
Anti-TRPC1 antibody used in IHC (Frozen sections) (IHC-Fr). GTX54859

Cat. No. GTX54859

Reference 1

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, ICC/IF, IHC-Fr, IP

Reactivity

 Human, Mouse, Rat
Package
50 μl ($639)
See all TRPC1 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB Assay dependent
ICC/IF Assay dependent
IHC-Fr Assay dependent
IP Assay dependent
Not tested in other applications.

Calculated MW

91 kDa. ( Note )

Predict Reactivity

Rabbit, Bovine(>80% identity)

PROPERTIES

Form

Liquid

Buffer

PBS, 1% BSA

Preservative

0.05% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.8 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Peptide QLYDKGYTSKEQKDC, corresponding to amino acid residues 557-571 (Intracellular) of human TRPC1 (Accession  : P48995).

Purification

Purified by antigen-affinity chromatography

Conjugation

Unconjugated

RRID

AB_2887898

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

transient receptor potential cation channel subfamily C member 1 , HTRP-1 , TRP1

Cellular Localization

Membrane; Multi-pass membrane protein

Background

The protein encoded by this gene is a membrane protein that can form a non-selective channel permeable to calcium and other cations. The encoded protein appears to be induced to form channels by a receptor tyrosine kinase-activated phosphatidylinositol second messenger system and also by depletion of intracellular calcium stores. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

Database

Research Area

DATA IMAGES

Anti-TRPC1 antibody used in Western Blot (WB). GTX54859

GTX54859 WB Image

WB analysis of rat brain membrane lysate using GTX54859 TRPC1 antibody preincubated with or without immunogen peptide.
Dilution : 1:200

Anti-TRPC1 antibody used in IHC (Frozen sections) (IHC-Fr). GTX54859

GTX54859 IHC-Fr Image

IHC-Fr analysis of mouse cerebellum tissue using GTX54859 TRPC1 antibody.
Panel A : TRPC1 (red) appears in Purkinje cells (arrows) and in the molecular (Mol) and granule (Gran) layers.
Panel B : Staining with mouse anti-parvalbumin (PV) in the same brain section.
Panel C : Confocal merge of TRPC1 and PV demonstrates partial co-localization in the Purkinje and the molecular layers.

REFERENCE

Application Reference

Ge P et al. Cell Biol Int 2018; (Epub) TRPC1/3/6 inhibition attenuates the TGF-β1-induced epithelial-mesenchymal transition in gastric cancer via the Ras/Raf1/ERK signaling pathway.
Application : ICC/IF
Reactivity : Human
Submit a Reference

REVIEW

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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 639