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UHRF1 antibody [1H9-D3-E11]

Anti-UHRF1 antibody [1H9-D3-E11] used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX49190
Anti-UHRF1 antibody [1H9-D3-E11] used in Western Blot (WB). GTX49190

Cat. No. GTX49190

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 1H9-D3-E11

Isotype

 IgG2b

Application

 WB, ICC/IF

Reactivity

 Human, Mouse
Package
100 μg ($399)
See all UHRF1 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB Assay dependent
ICC/IF Assay dependent
Not tested in other applications.

Calculated MW

90 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

PBS, 0.5% BSA, 50% glycerol

Preservative

0.02% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Purified recombinant human UHRF1 protein fragments expressed in E.coil.

Purification

Purified by affinity chromatography

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

ubiquitin like with PHD and ring finger domains 1 , ICBP90 , Np95 , RNF106 , TDRD22 , hNP95 , hUHRF1 , huNp95

Cellular Localization

Nucleus

Background

This gene encodes a member of a subfamily of RING-finger type E3 ubiquitin ligases. The protein binds to specific DNA sequences, and recruits a histone deacetylase to regulate gene expression. Its expression peaks at late G1 phase and continues during G2 and M phases of the cell cycle. It plays a major role in the G1/S transition by regulating topoisomerase IIalpha and retinoblastoma gene expression, and functions in the p53-dependent DNA damage checkpoint. It is regarded as a hub protein for the integration of epigenetic information. This gene is up-regulated in various cancers, and it is therefore considered to be a therapeutic target. Multiple transcript variants encoding different isoforms have been found for this gene. A related pseudogene exists on chromosome 12. [provided by RefSeq, Feb 2014]

Database

Research Area

DATA IMAGES

Anti-UHRF1 antibody [1H9-D3-E11] used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX49190

GTX49190 ICC/IF Image

ICC/IF analysis of HeLa cells using UHRF1 antibody at a dilution of 1:200.

Anti-UHRF1 antibody [1H9-D3-E11] used in Western Blot (WB). GTX49190

GTX49190 WB Image

WB analysis of mouse heart, 293T, HeLaNE and HeLa lysates using UHRF1 antibody at a dilution of 1:1,000.

REFERENCE

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REVIEW

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SDS
Glycerol.pdf
Sodium Azide.pdf
Package List Price ($)
$ 399