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VEGF 165 + VEGF 121 antibody [2B86]

Anti-VEGF 165 + VEGF 121 antibody [2B86] used in IHC (Paraffin sections) (IHC-P). GTX52462

Cat No. GTX52462

Host

Mouse

Clonality

Monoclonal

Clone Name

2B86

Isotype

IgG2

Application

WB, IHC-P

Reactivity

Human
Package
100 μg ($329)

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB 1:400 - 1:1600
IHC-P 1:25 - 1:50
Not tested in other applications.

Calculated MW

27 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

PBS

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

200 μg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Human VEGF-A 165 recombinant protein

Purification

Protein G purified
From tissue culture supernatant

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

MVCD1 , VEGF , VEGFA , VPF , vascular endothelial growth factor A

Cellular Localization

Secreted

Background

This gene is a member of the PDGF/VEGF growth factor family. It encodes a heparin-binding protein, which exists as a disulfide-linked homodimer. This growth factor induces proliferation and migration of vascular endothelial cells, and is essential for both physiological and pathological angiogenesis. Disruption of this gene in mice resulted in abnormal embryonic blood vessel formation. This gene is upregulated in many known tumors and its expression is correlated with tumor stage and progression. Elevated levels of this protein are found in patients with POEMS syndrome, also known as Crow-Fukase syndrome. Allelic variants of this gene have been associated with microvascular complications of diabetes 1 (MVCD1) and atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been described. There is also evidence for alternative translation initiation from upstream non-AUG (CUG) codons resulting in additional isoforms. A recent study showed that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is antiangiogenic. Expression of some isoforms derived from the AUG start codon is regulated by a small upstream open reading frame, which is located within an internal ribosome entry site. [provided by RefSeq, Nov 2015]

Database

Research Area

DATA IMAGES

Anti-VEGF 165 + VEGF 121 antibody [2B86] used in IHC (Paraffin sections) (IHC-P). GTX52462

GTX52462 IHC-P Image

IHC-P analysis of formalin fixed human placenta tissue using GTX52462 VEGF 165 + VEGF 121 antibody [2B86].

REFERENCE

There are currently no references for VEGF 165 + VEGF 121 antibody [2B86] (GTX52462). Be the first to share your publications with this product.

REVIEW

There are currently no reviews for VEGF 165 + VEGF 121 antibody [2B86] (GTX52462). Be the first to share your experience with this product.
SDS
PBS.pdf