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VEGF antibody [MAB0705]

Anti-VEGF antibody [MAB0705] used in Neutralizing/Blocking/Inhibition (Neutralizing/Inhibition). GTX53467

Cat No. GTX53467

Host

Mouse

Clonality

Monoclonal

Clone Name

MAB0705

Isotype

IgG1

Application

WB, Neutralizing/Inhibition

Reactivity

Human, Mouse
Package
100 μg ($359)

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
WB Assay dependent
Neutralizing/Inhibition Assay dependent
Not tested in other applications.

Calculated MW

25 kDa. ( Note )

PROPERTIES

Form

Liquid

Buffer

PBS

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Mouse

Immunogen

recombinant mouse VEGF

Purification

Protein G purified
From tissue culture supernatant

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Cellular Localization

Secreted,Cell membrane

Background

This gene is a member of the PDGF/VEGF growth factor family. It encodes a heparin-binding protein, which exists as a disulfide-linked homodimer. This growth factor induces proliferation and migration of vascular endothelial cells, and is essential for both physiological and pathological angiogenesis. Disruption of this gene in mice resulted in abnormal embryonic blood vessel formation. This gene is upregulated in many known tumors and its expression is correlated with tumor stage and progression. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. There is also evidence for alternative translation initiation from upstream non-AUG (CUG) codons resulting in additional isoforms. A recent study showed that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is antiangiogenic. Expression of some isoforms derived from the AUG start codon is regulated by a small upstream open reading frame, which is located within an internal ribosome entry site.[provided by RefSeq, Nov 2015]

Database

Research Area

DATA IMAGES

Anti-VEGF antibody [MAB0705] used in Neutralizing/Blocking/Inhibition (Neutralizing/Inhibition). GTX53467

GTX53467 Neutralizing/Inhibition Image

Neutralizing/Blocking assay analysis of mouse endothelial cells stimulated with mouse VEGF for 20 mins in the absence or presence of GTX53467 VEGF antibody [MAB0705]. The level of p-VEGFR2 was detected using anti-phospho-VEGF2.

REFERENCE

There are currently no references for VEGF antibody [MAB0705] (GTX53467). Be the first to share your publications with this product.

REVIEW

There are currently no reviews for VEGF antibody [MAB0705] (GTX53467). Be the first to share your experience with this product.
SDS
PBS.pdf