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XPC antibody

Anti-XPC antibody used in Western Blot (WB). GTX70308

Cat. No. GTX70308

Reference 1

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB

Reactivity

 Human
Package
100 μl ($399)
See all XPC products

APPLICATION

Application Note

For WB: Load 40ug cell lysate/lane. Use at a dilution of 1:500-1:1000. Optimal dilutions/concentratons should be determined by the researcher.

Calculated MW

106 kDa. ( Note )

Positive Control

HeLa whole cell lysate

Product Note

Human XPC

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

No Preservative

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.5 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Peptide conjugated to a carrier protein

Purification

Affinity purified with antigen

Conjugation

Unconjugated

RRID

AB_371452

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

XPC complex subunit, DNA damage recognition and repair factor , RAD4 , XP3 , XPCC , p125

Cellular Localization

Nucleus , Cytoplasm

Background

The protein encoded by this gene is a key component of the XPC complex, which plays an important role in the early steps of global genome nucleotide excision repair (NER). The encoded protein is important for damage sensing and DNA binding, and shows a preference for single-stranded DNA. Mutations in this gene or some other NER components can result in Xeroderma pigmentosum, a rare autosomal recessive disorder characterized by increased sensitivity to sunlight with the development of carcinomas at an early age. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2017]

Database

Research Area

DATA IMAGES

Anti-XPC antibody used in Western Blot (WB). GTX70308

GTX70308 WB Image

Western blot image of human XPC from HeLa whole cell lysate (40ug/lane) detected using rabbit polyclonal (lanes 1 and 2, catalog numbers GTX70308 (1:500) and GTX70309, respectively) or monoclonal (lane 3, catalog number GTX70294) antibodies.

REFERENCE

Application Reference

Boucher D et al. Sci Rep 2021; 11 (1) : 20256 hSSB2 (NABP1) is required for the recruitment of RPA during the cellular response to DNA UV damage.
Application : WB
Reactivity : Human
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Package List Price ($)
$ 399