GeneTex
United States (US)

sRANK Ligand antibody

GTX31202_IHC-P_18121410_508.jpg
GTX31202_IHC-P_1_18121410_462.jpg
GTX31202_IHC-P_2_18121410_131.jpg

Cat No. GTX31202

Host Rabbit
Clonality Polyclonal
Application WB, IHC-P, ELISA
Reactivity Human
APPLICATION

Calculated MW

35 kDa. ( Note )
PROPERTIES

Form

Liquid

Buffer

PBS, pH 7.2

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Antigen Species

Human

Immunogen

E.coli derived Recombinant Human sRANK Ligand

Purification

Affinity Purified

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
TARGET

Synonyms

Tnf Superfamily Member 11,Cd254,Odf,Opgl,Optb2,Rankl,Tnlg6B,Trance,Hrankl2,Sodf,Tnfsf11

Background

This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced tra

Database

Research Area

DATA IMAGES
GTX31202_IHC-P_18121410_508.jpg

GTX31202 IHC-P Image

IHC-P analysis of human metastatic carcinoma of lymph node from breast tissue using sRANK Ligand antibody at a concentration of 0.25 μg/ml. An HRP-labeled polymer detection system was used with a DAB chromogen. Heat induced antigen retrieval with a pH 6.0 Sodium Citrate buffer is recommended.

GTX31202_IHC-P_1_18121410_462.jpg

GTX31202 IHC-P Image

IHC-P analysis of human metastatic carcinoma of lymph node from breast tissue using sRANK Ligand antibody at a concentration of 0.25 μg/ml. An HRP-labeled polymer detection system was used with a DAB chromogen. Heat induced antigen retrieval with a pH 6.0 Sodium Citrate buffer is recommended.

GTX31202_IHC-P_2_18121410_131.jpg

GTX31202 IHC-P Image

IHC-P analysis of human metastatic carcinoma of lymph node from breast tissue using sRANK Ligand antibody at a concentration of 0.25 μg/ml. An HRP-labeled polymer detection system was used with a DAB chromogen. Heat induced antigen retrieval with a pH 6.0 Sodium Citrate buffer is recommended.

Package List Price ($)
$ 319