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Cathepsin D antibody [GT1232]

Cat No. GTX01540
Host: Rabbit
Clonality: Monoclonal
Application: WB, IHC-P
Reactivity: Hu, Ms
Package: 100 μl
Anti-Cathepsin D antibody [GT1232] used in Western Blot (WB). GTX01540

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Cathepsin D antibody

Cat No. GTX133019
Host: Rabbit
Clonality: Polyclonal
Application: WB, ICC/IF
Reactivity: Hu, Ms
Package: 100 μl, 25 μl
Anti-Cathepsin D antibody used in Western Blot (WB). GTX133019

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Cathepsin D antibody [N2C2], Internal

Cat No. GTX112847
Host: Rabbit
Clonality: Polyclonal
Application: WB
Reactivity: Hu
Package: 100 μl, 25 μl

Cathepsin D antibody [4G2]

Cat No. GTX53801
Host: Mouse
Clonality: Monoclonal
Application: WB, IHC-P, ELISA
Reactivity: Hu
Package: 100 μl
Anti-Cathepsin D antibody [4G2] used in Western Blot (WB). GTX53801

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Cathepsin D antibody

Cat No. GTX56269
Host: Rabbit
Clonality: Polyclonal
Application: WB, IHC-P
Reactivity: Hu
Package: 100 μl
Anti-Cathepsin D antibody used in Western Blot (WB). GTX56269

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Cathepsin D Light chain antibody

Cat No. GTX56271
Host: Rabbit
Clonality: Polyclonal
Application: WB
Reactivity: Hu, Ms, Rat
Package: 100 μl
Anti-Cathepsin D Light chain antibody used in Western Blot (WB). GTX56271

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Cathepsin D Heavy chain antibody

Cat No. GTX56270
Host: Rabbit
Clonality: Polyclonal
Application: WB
Reactivity: Hu, Ms, Rat
Package: 100 μl
Anti-Cathepsin D Heavy chain antibody used in Western Blot (WB). GTX56270

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Cathepsin D antibody [CTD-19]

Cat No. GTX26313
Host: Mouse
Clonality: Monoclonal
Application: WB, IHC-P, ELISA
Reactivity: Hu
Product Note: Cathepsins are lysosomal proteases that play an important role in the intracellular degradation of exogenous and endogenous proteins, in activation of enzyme precursors, and in tumor invasion and metastasis. They are normally localized in lysosomes of almost all mammalian cells, but under certain conditions they can be secreted from the cells.Cathepsin D (CD, EC 3.4.23.5), an aspartyl endopeptidase, is induced by estrogen in certain estrogen receptor (ER)-positive breast cancer cell lines, but is produced constitutively by ER-negative cell lines. Cathepsin D is synthesized as a 52 kDa inactive precursor (pro-cathepsin D). Proteolytic removal of the amino-terminal 43 amino acid fragment and cleavage at an internal site results in an enzymatically active 48 kDa heterodimer consisting of two chains of 14 and 34 kDa.The level of CD synthesized by cells is increased in response to mitogenic signals from estrogen, EGF, FGF, and IGF- I. The ability of tumor cells to invade the extracellular matrix has been attributed to cathepsins released by tumor cells or associated with the plasma membrane of tumor cells. CD is capable of digesting extracellular matrix proteins in in vivo models. Transfection of the CD gene into rat cells increases their tumorigenicity when injected into nude mice. Indeed, the concentrations of CD are significantly higher in breast carcinomas than in either normal breast tissues or benign breast tumors.
Package: 100 μl

Cathepsin D (cleaved Gly65) antibody

Cat No. GTX86884
Host: Rabbit
Clonality: Polyclonal
Application: WB
Reactivity: Mk
Product Note: Cathepsin D (cleaved Gly65) antibody detects endogenous levels of fragment of activated CATD resulting from cleavage adjacent to Gly65.
Package: 100 μg
Anti-Cathepsin D (cleaved Gly65) antibody used in Western Blot (WB). GTX86884

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Cathepsin D (cleaved Leu169) antibody

Cat No. GTX86942
Host: Rabbit
Clonality: Polyclonal
Application: WB
Reactivity: Hu
Product Note: Cathepsin D (cleaved Leu169) antibody detects endogenous levels of fragment of activated CATD resulting from cleavage adjacent to Leu169.
Package: 100 μg
Anti-Cathepsin D (cleaved Leu169) antibody used in Western Blot (WB). GTX86942

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