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GABA A Receptor alpha 1 antibody [N1C1]

Anti-GABA A Receptor alpha 1 antibody [N1C1] used in IHC (Paraffin sections) (IHC-P). GTX104027
Anti-GABA A Receptor alpha 1 antibody [N1C1] used in IHC (Paraffin sections) (IHC-P). GTX104027
Anti-GABA A Receptor alpha 1 antibody [N1C1] used in Western Blot (WB). GTX104027

Cat. No. GTX104027

Reference 1

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, IHC-P

Reactivity

 Human, Rat
Package
100 μl ($399),
25 μl ($169)
See all GABA A Receptor alpha 1 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1:500-1:3000
IHC-P 1:100-1:1000
Not tested in other applications.

Calculated MW

52 kDa. ( Note )

Predict Reactivity

Mouse, Zebrafish, Rabbit, Bovine, Chicken, Rhesus Monkey(>80% identity)

PROPERTIES

Form

Liquid

Buffer

PBS, 20% Glycerol

Preservative

0.025% ProClin 300

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Recombinant protein encompassing a sequence within the Extracellular domain of human GABA A Receptor alpha 1. The exact sequence is proprietary.

Purification

Purified by antigen-affinity chromatography.

Conjugation

Unconjugated

RRID

AB_2037030

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

gamma-aminobutyric acid type A receptor alpha1 subunit , ECA4 , EIEE19 , EJM , EJM5

Cellular Localization

Cell junction , synapse , postsynaptic cell membrane; Multi-pass membrane protein , Cell membrane; Multi-pass membrane protein

Background

This gene encodes a gamma-aminobutyric acid (GABA) receptor. GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. GABA-A receptors are pentameric, consisting of proteins from several subunit classes: alpha, beta, gamma, delta and rho. Mutations in this gene cause juvenile myoclonic epilepsy and childhood absence epilepsy type 4. Multiple transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq]

Database

Research Area

DATA IMAGES

Anti-GABA A Receptor alpha 1 antibody [N1C1] used in IHC (Paraffin sections) (IHC-P). GTX104027

GTX104027 IHC-P Image

GABA A Receptor alpha 1 antibody [N1C1] detects GABA A Receptor alpha 1 protein at cytoplasm in rat brain by immunohistochemical analysis.
Sample: Paraffin-embedded rat brain.
GABA A Receptor alpha 1 antibody [N1C1] (GTX104027) diluted at 1:500.

Antigen Retrieval: Citrate buffer, pH 6.0, 15 min

Anti-GABA A Receptor alpha 1 antibody [N1C1] used in IHC (Paraffin sections) (IHC-P). GTX104027

GTX104027 IHC-P Image

GABA A Receptor alpha 1 antibody [N1C1] detects GABA A Receptor alpha 1 protein at cytoplasm in rat brain by immunohistochemical analysis.
Sample: Paraffin-embedded rat brain.
GABA A Receptor alpha 1 antibody [N1C1] (GTX104027) diluted at 1:500.

Antigen Retrieval: Citrate buffer, pH 6.0, 15 min

Anti-GABA A Receptor alpha 1 antibody [N1C1] used in Western Blot (WB). GTX104027

GTX104027 WB Image

GABA A Receptor alpha 1 antibody detects GABA A Receptor alpha 1 protein by Western blot analysis. Various whole cell extracts (30 μg) were separated by 10% SDS-PAGE, and the membrane was blotted with GABA A Receptor alpha 1 antibody (GTX104027) diluted by 1:500.

REFERENCE

Application Reference

Barzroodi Pour M et al. Life Sci 2019; 232 : 116667 The effect of exercise on GABA signaling pathway in the model of chemically induced seizures.
Application : IHC-P
Reactivity : Rat
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REVIEW

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SDS
Glycerol.pdf
Thimerosal.pdf
Package List Price ($)
$ 399
$ 169