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REM antibody [24E4]

Cat. No. GTX13058

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 24E4

Isotype

 IgG1

Application

 WB, IP

Reactivity

 Human, Mouse
Package
50 μg ($399)
See all REM products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1 μg/ml
IP Assay dependent
Not tested in other applications.

Calculated MW

33 kDa. ( Note )

Positive Control

C2C12

PROPERTIES

Form

Liquid

Buffer

PBS, 20mM Sodium Phosphate, 150mM Sodium Chloride, 50% Glycerol

Preservative

3mM Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Mouse

Immunogen

recombinant mouse Rem.

Purification

Purified immunoglobulin

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

RRAD and GEM like GTPase 1 , GD:REM , GES

Background

REM (Rad and Gem related GTP binding protein) is a member of the Rad/Gem/Kir subfamily of Ras-like GTPases and shares with other members of this subfamily some unusual structural features. Among these are nonconservative amino acid substitutions within guanine nucleotide binding and hydrolysis domains, unique effector domains, extended N- and C-termini, and a conserved C-terminal sequence thought to mediate membrane association but lacking a classical isoprenylation motif. REM, with a predicted molecular weight of 32.9 kDa, is most highly expressed in cardiac muscle and is expressed at more moderate levels in lung, kidney and skeletal muscle. REM is phosphorylated in vivo and has been shown to interact with several 14-3-3 isoforms. It has been reported that the GTP-bound form of a related Ras-like GTPase, GEM/kir, inhibits high-voltage activated Ca2+ channel activities by interacting directly with the ? subunit. The reduced channel activities are the result of a decreased a-subunit expression at the plasma membrane. This inhibition of L-type Ca2+ channels prevents Ca2+-triggered exocytosis in hormone-secreting cells. There are data that suggest that REM similarly regulates Ca2+ channel expression.

Database

Research Area

REFERENCE

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REVIEW

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SDS
PBS.pdf
Glycerol.pdf
Sodium Azide.pdf
Package List Price ($)
$ 399