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United States (US)

ERAB blocking peptide

Cat. No. GTX48613-PEP

Package
100 μg ($259)

APPLICATION

Product Note

The peptide was used in the production of GTX48613.

PROPERTIES

Form

Lyophilized powder

Buffer

Reconstitute with 200μl distilled water to obtain a 0.5mg/ml peptide solution. Lyophilized from 5% (v/v) acetonitrile/H₂O.

Preservative

No preservative

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Region/Sequence

CIRLDGAIRMQP

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

Hydroxysteroid 17-Beta Dehydrogenase 10 , 17B-Hsd10 , Abad , Camr , Dupxp11.22 , Erab , Hadh2 , Hcd2 , Hsd10Md , Mhbd , Mrpp2 , Mrx17 , Mrx31 , Mrxs10 , Schad , Sdr5C1 , Hsd17B10

Background

This gene encodes 3-hydroxyacyl-CoA dehydrogenase type II, a member of the short-chain dehydrogenase/reductase superfamily. The gene product is a mitochondrial protein that catalyzes the oxidation of a wide variety of fatty acids and steroids, and is a subunit of mitochondrial ribonuclease P, which is involved in tRNA maturation. The protein has been implicated in the development of Alzheimer disease, and mutations in the gene are the cause of 17beta-hydroxysteroid dehydrogenase type 10 (HSD10) deficiency. Several alternatively spliced transcript variants have been identified, but the full-length nature of only two transcript variants has been determined. [provided by RefSeq, Aug 2014]

Research Area

REFERENCE

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REVIEW

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Package List Price ($)
$ 259