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PDE1C antibody

Anti-PDE1C antibody used in Western Blot (WB). GTX14602
Anti-PDE1C antibody used in Western Blot (WB). GTX14602
Anti-PDE1C antibody used in Immunohistochemistry (IHC). GTX14602
Anti-PDE1C antibody used in Western Blot (WB). GTX14602
Anti-PDE1C antibody used in Western Blot (WB). GTX14602

Cat. No. GTX14602

Reference 1

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, ICC/IF, IP, ELISA, IHC

Reactivity

 Human, Mouse, Rat
Package
100 μg ($409)
See all PDE1C products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1:500-1:2000
ICC/IF 1:40-1:100
IP 1:200
ELISA 1:10000
IHC 1:40-1:100
Not tested in other applications.

Calculated MW

81 kDa. ( Note )

Product Note

This antibody does not cross-react with PDE1A, PDE1B, or other PDE family members. This antibody will label all PDE1C variants including PDE1C1, PDE1C2, and PDE1C3.

PROPERTIES

Form

Liquid

Buffer

Tris/Glycine, 0.5% BSA, 30% Glycerol

Preservative

0.02% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.5 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Synthetic peptide corresponding to unique amino acid sequence on PDE1C gene.

Purification

Purified by affinity chromatography

Conjugation

Unconjugated

RRID

AB_368824

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

phosphodiesterase 1C , DFNA74 , Hcam3 , cam-PDE 1C , hCam-3

Background

This gene encodes an enzyme that belongs to the 3'5'-cyclic nucleotide phosphodiesterase family. Members of this family catalyze hydrolysis of the cyclic nucleotides, cyclic adenosine monophosphate and cyclic guanosine monophosphate, to the corresponding nucleoside 5'-monophosphates. The enzyme encoded by this gene regulates proliferation and migration of vascular smooth muscle cells, and neointimal hyperplasia. This enzyme also plays a role in pathological vascular remodeling by regulating the stability of growth factor receptors, such as PDGF-receptor-beta. [provided by RefSeq, Jul 2016]

Database

DATA IMAGES

Anti-PDE1C antibody used in Western Blot (WB). GTX14602

GTX14602 WB Image

WB analysis of rat tissue lysates using GTX14602 PDE1C antibody.
Dilution : 1:250

Anti-PDE1C antibody used in Western Blot (WB). GTX14602

GTX14602 WB Image

WB analysis of PDE1C1 and PDE1C2 recombinant protein using GTX14602 PDE1C antibody.
Dilution : 1:500

Anti-PDE1C antibody used in Immunohistochemistry (IHC). GTX14602

GTX14602 IHC Image

IHC analysis of human ovarian medulla tissue using GTX14602 PDE1C antibody.
Dilution : 1:1500

Anti-PDE1C antibody used in Western Blot (WB). GTX14602

GTX14602 WB Image

WB analysis of rat brain tissue lysate using GTX14602 PDE1C antibody.
Dilution : 1:250

Anti-PDE1C antibody used in Western Blot (WB). GTX14602

GTX14602 WB Image

The data was published in the journal PLoS One in 2013.PMID: 23691025

REFERENCE

Application Reference

Guibinga GH et al. PLoS One 2013; 8 (5) : e63333 HPRT-deficiency dysregulates cAMP-PKA signaling and phosphodiesterase 10A expression: mechanistic insight and potential target for Lesch-Nyhan Disease?
Application : WB
Reactivity : Human
Submit a Reference

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Package List Price ($)
$ 409