APPLICATION
Application Note
*Optimal dilutions/concentrations should be determined by the researcher.
| Application |
Recommended Dilution |
| 0.2-2.5 ug/ml |
Not tested in other applications.
Calculated MW
Positive Control
DU145 , human fetal heart , human fetal liver , human ovary tumor , human placenta
PROPERTIES
Form
Liquid
Buffer
PBS, 2% Sucrose
Preservative
0.09% Sodium azide
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration
0.5-1 mg/ml (Please refer to the vial label for the specific concentration.)
Antigen Species
Human
Immunogen
A synthetic peptide corresponding to an Internal region of Human SLC19A3
Purification
Affinity Purified
Conjugation
Unconjugated
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
TARGET
Synonyms
solute carrier family 19 member 3 , BBGD , THMD2 , THTR2
Cellular Localization
Membrane
Background
This gene encodes a ubiquitously expressed transmembrane thiamine transporter that lacks folate transport activity. Mutations in this gene cause biotin-responsive basal ganglia disease (BBGD); a recessive disorder manifested in childhood that progresses to chronic encephalopathy, dystonia, quadriparesis, and death if untreated. Patients with BBGD have bilateral necrosis in the head of the caudate nucleus and in the putamen. Administration of high doses of biotin in the early progression of the disorder eliminates pathological symptoms while delayed treatment results in residual paraparesis, mild cognitive disability, or dystonia. Administration of thiamine is ineffective in the treatment of this disorder. Experiments have failed to show that this protein can transport biotin. Mutations in this gene also cause a Wernicke's-like encephalopathy.[provided by RefSeq, Jan 2010]
Database
Research Area
DATA IMAGES
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GTX46980 WB Image
WB analysis of human fetal heart tissue using GTX46980 SLC19A3 antibody at 1μg/ml.
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GTX46980 WB Image
WB analysis of DU145 cells using GTX46980 SLC19A3 antibody at 0.2-1μg/ml.
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GTX46980 WB Image
WB analysis of human fetal liver tissue using GTX46980 SLC19A3 antibody at 1μg/ml.
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GTX46980 WB Image
WB analysis of human ovary tumor tissue using GTX46980 SLC19A3 antibody at 1μg/ml.
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GTX46980 WB Image
WB analysis of human placenta tissue using GTX46980 SLC19A3 antibody at 1μg/ml.
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REFERENCE
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REVIEW
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