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CBX2 antibody

Anti-CBX2 antibody used in IHC (Paraffin sections) (IHC-P). GTX117711
Anti-CBX2 antibody used in Western Blot (WB). GTX117711
Anti-CBX2 antibody used in IHC (Paraffin sections) (IHC-P). GTX117711
Anti-CBX2 antibody used in Western Blot (WB). GTX117711

Cat. No. GTX117711

Reference 3

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, IHC-P

Reactivity

 Human, Mouse
Package
100 μl ($399),
25 μl ($169)
See all CBX2 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1:500-1:3000
IHC-P 1:100-1:1000
Not tested in other applications.

Calculated MW

56 kDa. ( Note )

Positive Control

A431

PROPERTIES

Form

Liquid

Buffer

0.1M Tris, 0.1M Glycine, 20% Glycerol

Preservative

0.01% Thimerosal

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

0.9 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Recombinant protein encompassing a sequence within the center region of human CBX2. The exact sequence is proprietary.

Purification

Purified by antigen-affinity chromatography.

Conjugation

Unconjugated

RRID

AB_11176793

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

chromobox 2 , CDCA6 , M33 , SRXY5

Cellular Localization

Nucleus

Background

This gene encodes a component of the polycomb multiprotein complex, which is required to maintain the transcriptionally repressive state of many genes throughout development via chromatin remodeling and modification of histones. Disruption of this gene in mice results in male-to-female gonadal sex reversal. Mutations in this gene are also associated with gonadal dysgenesis in humans. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.

Database

Research Area

DATA IMAGES

Anti-CBX2 antibody used in IHC (Paraffin sections) (IHC-P). GTX117711

GTX117711 IHC-P Image

Immunohistochemical analysis of paraffin-embedded C2C12 xenograft, using CBX2(GTX117711) antibody at 1:500 dilution.
Antigen Retrieval: Trilogy™ (EDTA based, pH 8.0) buffer, 15min

Anti-CBX2 antibody used in Western Blot (WB). GTX117711

GTX117711 WB Image

Sample (30 ug of whole cell lysate)
A: A431
12% SDS PAGE
GTX117711 diluted at 1:1000

Anti-CBX2 antibody used in IHC (Paraffin sections) (IHC-P). GTX117711

GTX117711 IHC-P Image

The data was published in the journal Sci Rep in 2016. PMID: 27181215

Anti-CBX2 antibody used in Western Blot (WB). GTX117711

GTX117711 WB Image

The data was published in the journal Sci Rep in 2016. PMID: 27181215

REFERENCE

Application Reference

Wang B et al. J Coll Physicians Surg Pak 2021; 31 (9) : 1051-1056 CBX2 Expression in Colorectal Mucosa-adenoma-adenocarcinoma Sequence.
Application : IHC-P
Reactivity : Mouse
Mao J et al. J Cancer 2019; 10 (12) : 2706-2719 CBX2 Regulates Proliferation and Apoptosis via the Phosphorylation of YAP in Hepatocellular Carcinoma.
Application : WB
Reactivity : Human
Bian F et al. Sci Rep 2016; 6 : 26061 Polycomb repressive complex 1 controls uterine decidualization.
Application : WB
Reactivity : Mouse
Submit a Reference

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SDS
Glycerol.pdf
Thimerosal.pdf
Package List Price ($)
$ 399
$ 169