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Mu Opioid receptor antibody [N1], N-term

Anti-Mu Opioid receptor antibody [N1], N-term used in Western Blot (WB). GTX108125
Anti-Mu Opioid receptor antibody [N1], N-term used in IHC (Paraffin sections) (IHC-P). GTX108125

Cat. No. GTX108125

Reference 5

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, IHC-P

Reactivity

 Human
Package
100 μl ($399),
25 μl ($169)
See all Mu Opioid receptor products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1:500-1:3000
IHC-P 1:100-1:1000
Not tested in other applications.

Calculated MW

45 kDa. ( Note )

Positive Control

A431 , H1299

PROPERTIES

Form

Liquid

Buffer

PBS, 1% BSA, 20% Glycerol

Preservative

0.01% Thimerosal

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Synthetic peptide encompassing a sequence within the Extracellular domain of human Mu Opioid receptor. The exact sequence is proprietary.

Purification

Purified by antigen-affinity chromatography.

Conjugation

Unconjugated

RRID

AB_1951066

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

opioid receptor mu 1 , LMOR , M-OR-1 , MOP , MOR , MOR1 , OPRM

Background

The OPRM1 gene encodes the mu opioid receptor, which is the primary site of action for the most commonly used opioids, including morphine, heroin, fentanyl, and methadone. It is also the primary receptor for endogenous opioid peptides beta-endorphin (see POMC, MIM 176830) and the enkephalins (see PENK, MIM 131330). The OPRM1 receptor is a membrane of the G protein-coupled receptor family (Bond et al., 1998 [PubMed 9689128]). There are at least 3 types of opioid receptors, mu, kappa (OPRK1; MIM 165196), and delta (OPRD1; MIM 165195), each with a distinct pharmacologic profile (Chen et al., 1993 [PubMed 8393525]).[supplied by OMIM]

Database

Research Area

DATA IMAGES

Anti-Mu Opioid receptor antibody [N1], N-term used in Western Blot (WB). GTX108125

GTX108125 WB Image

Sample(30 μg of whole cell lysate)
A:A431(GTX27909)
B:H1299
7.5% SDS PAGE
GTX108125 diluted at 1:500

Anti-Mu Opioid receptor antibody [N1], N-term used in IHC (Paraffin sections) (IHC-P). GTX108125

GTX108125 IHC-P Image

Immunohistochemical analysis of paraffin-embedded Cal27 xenograft, using mu Opioid receptor(GTX108125) antibody at 1:500 dilution.
Antigen Retrieval: Citrate buffer, pH 6.0, 15 min

REFERENCE

Application Reference

Singleton PA et al. Br J Anaesth 2014; (Epub) Increased μ-opioid receptor expression in metastatic lung cancer.
Application : IHC-P
Reactivity : Human
Lennon FE et al. PLoS One 2014; 9 (3) : e91577 The Mu Opioid Receptor Promotes Opioid and Growth Factor-Induced Proliferation, Migration and Epithelial Mesenchymal Transition (EMT) in Human Lung Cancer.
Application : WB
Reactivity : Human
Sillivan SE et al. Biol Psychiatry 2013; 74 (7) : 511-9 ELK1 transcription factor linked to dysregulated striatal mu opioid receptor signaling network and OPRM1 polymorphism in human heroin abusers.
Application : WB
Reactivity : Human
Lennon FE et al. Anesthesiology 2012; 116 (4) : 857-67 Overexpression of the μ-opioid receptor in human non-small cell lung cancer promotes Akt and mTOR activation, tumor growth, and metastasis.
Application : WB
Reactivity : Human
Mathew B et al. Anesth Analg 2011; 112 (3) : 558-67 The novel role of the mu opioid receptor in lung cancer progression: a laboratory investigation.
Application : WB
Reactivity : Human
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SDS
PBS.pdf
Glycerol.pdf
Thimerosal.pdf
Package List Price ($)
$ 399
$ 169