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RASD2 antibody

Anti-RASD2 antibody used in Western Blot (WB). GTX85428
Anti-RASD2 antibody used in IHC (Paraffin sections) (IHC-P). GTX85428
Anti-RASD2 antibody used in IHC (Paraffin sections) (IHC-P). GTX85428

Cat. No. GTX85428

Reference 2

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, IHC-P, ELISA, IHC

Reactivity

 Human, Mouse, Rat
Package
100 μg ($399)
See all RASD2 products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
WB 1 - 2 μg/mL
IHC-P 2.5 μg/mL
ELISA Assay dependent
IHC Assay dependent
Not tested in other applications.

Calculated MW

30 kDa. ( Note )

Positive Control

Human Colon Tissue Lysate(GTX27928)

Product Note

This antibody is specific for RASD2 C-Terminus

PROPERTIES

Form

Liquid

Buffer

PBS

Preservative

0.02% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

RASD2 antibody was raised against a 15 amino acid synthetic peptide near the carboxy terminus of the human RASD2.The immunogen is located within the last 50 amino acids of RASD2.

Purification

Purified by antigen-affinity chromatography

Conjugation

Unconjugated

RRID

AB_10724454

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

RASD family member 2 , Rhes , TEM2

Cellular Localization

Cell membrane

Background

Rhes, also known as tumor endothelial marker 2 (TEM2), is a small GTP-binding protein that is predominantly expressed in the striatal region of the brain. This protein belongs to the RASD subfamily of Ras-related GTP-binding protein superfamily and is thought to play a role in the normal development and function of the brain as mice lacking this gene showed increased anxiety levels and motor coordination deficits. Rhes was identified as TEM2 through analysis of genes whose expression was upregulated in tumor endothelium. Tumor endothelial markers are significantly up-regulated during angiogenesis and neoangiogenesis that are crucial for the growth of solid tumors. TEMs localized on the cell surface and conserved across species are of particular interest for future development of anti-angiogenic therapies.

Database

Research Area

DATA IMAGES

Anti-RASD2 antibody used in Western Blot (WB). GTX85428

GTX85428 WB Image

WB analysis of human colon tissue lysate using GTX85428 RASD2 antibody.
Working concentration : (A) 1 and (B) 2 μg/ml

Anti-RASD2 antibody used in IHC (Paraffin sections) (IHC-P). GTX85428

GTX85428 IHC-P Image

IHC-P analysis of human colon tissue using GTX85428 RASD2 antibody.
Working concentration : 20 μg/ml

Anti-RASD2 antibody used in IHC (Paraffin sections) (IHC-P). GTX85428

GTX85428 IHC-P Image

IHC-P analysis of human colon tissue using GTX85428 RASD2 antibody.
Working concentration : 2.5 μg/ml

REFERENCE

Application Reference

Pan Y et al. Front Aging Neurosci 2023; 15 : 1237018 Rhes depletion promotes striatal accumulation and aggregation of mutant huntingtin in a presymptomatic HD mouse model.
Hernandez I et al. Sci Transl Med 2019; 11 (485) A farnesyltransferase inhibitor activates lysosomes and reduces tau pathology in mice with tauopathy.
Application : IHC
Reactivity : Mouse
Submit a Reference

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SDS
PBS.pdf
Sodium Azide.pdf
Package List Price ($)
$ 399