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Cancer Stem Cells

Cancer Stem Cells

Cancer stem cells (CSCs) are increasingly being recognized as the key determinative cells of malignancies. CSCs are described as relatively quiescent cells capable of self-renewal and the generation of more differentiated daughter cells that constitute the bulk of the tumor mass. While there is still debate as to the existence of a single subset of CSCs versus a collection of CSC variants in some tumors, a growing body of literature links CSCs to all steps of tumorigenesis, from initiation to metastasis. Even more ominously, however, evidence suggests that these cells are responsible for therapeutic resistance and relapse, with their persistence often meaning a poor clinical prognosis. For these reasons, CSC biology has become a vigorously studied area of cancer research.

Cancer Stem Cells Markers

Breast Colon Glioma Liver Lung Melanoma Ovarian Pancreatic Prostate
ALDH1 ABCB5 A2B5 ALDH1 ABCG2 ABCB5 ALDH1 ABCG2 A2B1
CD24 ALDH1 CD15 CD13 ALDH1 ALDH1 CD24 ALDH1 ALDH1
CD44 CD24 CD90 CD24 CD90 CD20 CD44 CD24 CD24
CD90 CD26  CD133 CD44 CD117 CD34 CD117 CD44 CD44
CD133 CD29  α6-integrin CD90 CD133 CD117 CD133 CD133  CD133
α6-integrin CD44  Nestin CD133   CD133   c-Met  CD166
EpCAM CD133   EpCAM   CD166   CXCR4  α2β1-integrin
p63 CD166   ICAM1   CD271   Nestin  α6-integrin
  EpCAM   Sall4   Nestin   EpCAM  
  LGR5              

 

Selected Cancer Stem Cells Markers

     

ALDH1A1 antibody (GTX123973)

c-Met antibody [C3], C-term (GTX100637)

  

Integrin beta 1 / CD29 antibody (GTX128839)

 
 
 

CD44 antibody [GT462] (GTX628895)

   

CD54 / ICAM1 antibody [N1C2](GTX100450)

CD90/Thy1 antibody (GTX130072)

 
 

EpCAM antibody [N3C3] (GTX113091)

Nestin antibody [GT623] (GTX630201)

 
   
 
Cat. No. Product Name Host & Clonality Reactivity Applications  
GTX14538 A2B5 antibody [105] Ms mAb Hu, Ms, Rat ICC/IF  
GTX60661 ABCB5 antibody [5H3C6] Ms mAb Hu ELISA, FACS, ICC/IF, IHC-P, WB
GTX100437 ABCG2 antibody Rb pAb Hu, Ms IHC-P, WB
GTX23380 ABCG2 antibody [BXP-21] Ms mAb Hu FACS, ICC/IF, IHC-Fr, IHC-P, WB
GTX123973 ALDH1A1 antibody Rb pAb Hu, Ms, Rat ICC/IF, IHC-P, WB
GTX123426 ALDH1A1 antibody Rb pAb Hu, Ms, Rat ICC/IF, IHC-P, WB  
GTX123974 ALDH1A1 antibody Rb pAb Hu ICC/IF, IHC-P, WB  
GTX100043 ALDH1A1 antibody [C3], C-term Rb pAb Hu, Ms ICC/IF, IHC-P, WB
GTX115148 ALDH1A2 antibody [C1C3] Rb pAb Hu, Ms, Rat IHC-P, WB  
GTX115147 ALDH1A2 antibody [N1N3] Rb pAb Hu, Ms, Rat WB  
GTX633822 ALDH1A3 antibody [GT926] Ms mAb Hu ICC/IF, WB
GTX110784 ALDH1A3 antibody [N2C2], Internal Rb pAb Hu ICC/IF, IHC-P, WB
GTX32525 c-Kit antibody Rb pAb Hu WB  
GTX102788 CD13 antibody Rb pAb Hu IHC-P, WB  
GTX42441 CD13 antibody [WM15] (Low endotoxin, azide free) Ms mAb Hu, RMK ELISA, FACS, IHC-Fr, IP, Functional Assay
GTX60471 CD133 antibody [3F10] Ms mAb Hu ELISA, FACS, IHC-P
GTX100567 CD133 antibody [C1C2], Internal Rb pAb Hu FACS, IHC-P, WB  
GTX102109 CD133 antibody [N1C1] Rb pAb Hu WB  
GTX130098 CD166 antibody Rb pAb Hu, Ms, Rat WB  
GTX60782 CD166 antibody [8E12C7] Ms mAb Hu ELISA, FACS, ICC/IF, IHC-P, WB  
GTX100209 CD20 antibody [C2C3], C-term Rb pAb Hu ICC/IF, WB  
GTX74945 CD24 antibody [SN3] Ms mAb Hu, Chmp FACS, IHC-Fr
GTX84602 CD26 antibody [11D7] Ms mAb Hu, Ms ELISA, FACS, ICC/IF, IHC-P, WB  
GTX102262 p75 NGF Receptor / CD271 antibody Rb pAb Hu, Ms, Rat ICC/IF, IHC-Fr, IHC-P, WB  
GTX128839 Integrin beta 1 / CD29 antibody Rb pAb Hu, Ms, Dog, Rat ICC/IF, IHC-P, IP, WB  
GTX112971 Integrin beta 1 / CD29 antibody Rb pAb Hu ICC/IF, IHC-P, WB   
GTX28158 CD34 antibody [MEC14.7] Rat mAb Hu, Ms, Rb ELISA, FACS, ICC/IF, IHC, IHC-Fr, IHC-P, IP, WB
GTX75411 CD34 antibody [MEC14.7] (FITC) Rat mAb Hu, Ms FACS, ICC/IF, IHC
GTX42057 CD34 antibody [MEC14.7] (Low endotoxin, azide free) Rat mAb Hu, Ms FACS, ICC/IF, IHC, IHC-P, IP
GTX75414 CD34 antibody [MEC14.7] (PE) Rat mAb Hu, Ms, Rb FACS, ICC/IF, IHC
GTX102111 CD44 antibody Rb pAb Hu, Ms, Rb ICC/IF, IHC, IHC-Fr, IHC-P, WB    
GTX628895 CD44 antibody [GT462] Ms mAb Hu FACS, IHC-P, WB    
GTX628472 CD44 antibody [GT981] Ms mAb Hu, Ms ICC/IF, IHC-P, WB  
GTX112893 CD44 antibody [N1N2], N-term Rb pAb Hu, Rat IHC-P, WB  
GTX75045 Integrin alpha 6 antibody [450-30A] (FITC) Ms mAb Hu, Rb FACS
GTX100565 Integrin alpha 6 antibody [N3C2], Internal Rb pAb Hu, Ms, Rat ICC/IF, WB  
GTX78387 ICAM1 / CD54 antibody [1H4] Ms mAb Hu FACS, ICC/IF, IHC-Fr, IHC-P, WB
GTX100451 ICAM1 / CD54 antibody [C1C3] Rb pAb Hu WB  
GTX100450 ICAM1 / CD54 antibody [N1C2] Rb pAb Hu IHC-P, WB
GTX130072 CD90 antibody Rb pAb Hu, Ms IHC-Fr, WB
GTX11153 CD90 antibody [F15-42-1] Ms mAb Hu, ClMK FACS, ICC/IF, IHC-Fr, IP
GTX11155 CD90 antibody [F15-42-1] (FITC) Ms mAb Hu, ClMK FACS, IHC
GTX100637 c-Met antibody [C3], C-term Rb pAb Hu ICC/IF, IP, WB  
GTX631993 c-Met antibody [GT1586] Ms mAb Hu IP, WB
GTX631992 c-Met antibody [GT556] Ms mAb Hu IHC-P, IP, WB
GTX22074 CXCR4 antibody Rb pAb Hu, Ms ELISA, FACS, ICC/IF, IHC-Fr, IHC-P, IP, WB
GTX34705 EpCAM antibody [EGP40/837] Ms mAb Hu FACS, IHC-P  
GTX113091 EpCAM antibody [N3C3] Rb pAb Hu, Ms IHC-P, WB
GTX127928 hnRNP A2B1 antibody Rb pAb Hu, Ms, Rat ICC/IF, IHC-P, IP, WB  
GTX117578 hnRNP A2B1 antibody Rb pAb Hu ICC/IF, IHC-P, WB
GTX114475 hnRNP A2B1 antibody Rb pAb Hu ICC/IF, IHC-P, WB
GTX631935 LGR5 antibody [GT11312] Ms mAb Hu, Ms WB  
GTX133111 Nestin antibody Rb pAb Hu, Ms, Rat ICC/IF, WB
GTX630201 Nestin antibody [GT623] Ms mAb Hu, Ms ICC/IF, IHC-P, WB  
GTX102425 p63 antibody [N2C1], Internal Rb pAb Hu, Ms, Rat ICC/IF, IHC-Fr, IHC-P, IP, WB, PLA   
GTX633818 p63 antibody [GT1179] Ms mAb Hu ICC/IF, IHC-P, WB
GTX109983 SALL4 antibody [C1C2], Internal Rb pAb Hu, Ms, Pig ICC/IF, IHC-P, WB  

 

Literature
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Download the latest version of GeneTex's pamphlet of hot products.