| Background | This gene encodes the regulatory subunit of the inhibitor of kappaB kinase (IKK) complex, which activates NF-kappaB resulting in activation of genes involved in inflammation, immunity, cell survival, and other pathways. Mutations in this gene result in incontinentia pigmenti, hypohidrotic ectodermal dysplasia, and several other types of immunodeficiencies. Multiple transcript variants encoding different isoforms have been found for this gene. A pseudogene highly similar to this locus is located in an adjacent region of the X chromosome. [supplied by RefSeq] |
| Synonyms | AMCBX1 antibody, FIP-3 antibody, FIP3 antibody, Fip3p antibody, IKK-gamma antibody, IP antibody, IP1 antibody, IP2 antibody, IPD2 antibody, NEMO antibody, IKBKG antibody, inhibitor of nuclear factor kappa-B kinase subunit gamma antibody, incontinentia pigmenti antibody, ikB kinase subunit gamma antibody, IKKG antibody, NF-kappa-B essential modulator antibody, ikB kinase-associated protein 1 antibody, NF-kappa-B essential modifier antibody, I-kappa-B kinase subunit gamma antibody, IKKAP1 antibody, NFkappaB essential modulator antibody, IkB kinase gamma subunit antibody, inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma antibody |