| Full Name | LIM domain kinase 1 |
| Product Description | Rabbit Polyclonal antibody to LIMK1 (phospho Thr508) |
| Background | There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. LIMK1 is a serine/threonine kinase that regulates actin polymerization via phosphorylation and inactivation of the actin binding factor cofilin. This protein is ubiquitously expressed during development and plays a role in many cellular processes associated with cytoskeletal structure. This protein also stimulates axon growth and may play a role in brain development. LIMK1 hemizygosity is implicated in the impaired visuospatial constructive cognition of Williams syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Feb 2011] |
| Synonyms | LIMK Antibody , LIM domain kinase 1 Antibody , LIMK1 Antibody , LIMK-1 Antibody |
| Specificity | Recognizes endogenous levels of LIMK1/2 (pT508/505) protein. |
| Host | Rabbit |
| Clonality | Polyclonal |
| Target | LIMK1 (phospho Thr508) |
| Isotype | IgG |
| Immunogen | KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human LIMK1/2. The exact sequence is proprietary. |
| Antigen Species | Human |
| Species Reactivity | Human, Rat |
| Conjugation | Unconjugated |