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Caspase 3 antibody

Orthogonal
Anti-Caspase 3 antibody used in Western Blot (WB). GTX73090
Anti-Caspase 3 antibody used in IHC (Paraffin sections) (IHC-P). GTX73090

Cat. No. GTX73090

Reference 4

Host

 Rabbit

Clonality

 Polyclonal

Isotype

 IgG

Application

 WB, IHC-P, IP, IHC

Reactivity

 Human, Mouse, Rat, Rabbit
Package
500 μl ($399)
See all Caspase 3 products

APPLICATION

Application Note

For IHC-P: Use at a dilution of 1:1,000. For IP: Use at a dilution of 1:2,000. For WB: Use at a dilution of 1:500. Optimal dilutions/concentrations should be determined by the researcher.

Calculated MW

32 kDa. ( Note )

Positive Control

Jurkat Cells, Tonsil

PROPERTIES

Form

Liquid

Buffer

10mM PBS, 0.2% BSA

Preservative

0.1% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE.

Concentration

1 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Recombinant full length human caspase 3 protein.

Purification

Protein A affinity purified

Conjugation

Unconjugated

RRID

AB_367941

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

caspase 3 , CPP32 , CPP32B , SCA-1

Cellular Localization

Cytoplasm

Background

The protein encoded by this gene is a cysteine-aspartic acid protease that plays a central role in the execution-phase of cell apoptosis. The encoded protein cleaves and inactivates poly(ADP-ribose) polymerase while it cleaves and activates sterol regulatory element binding proteins as well as caspases 6, 7, and 9. This protein itself is processed by caspases 8, 9, and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. [provided by RefSeq, Aug 2017]

Database

Research Area

DATA IMAGES

Anti-Caspase 3 antibody used in Western Blot (WB). GTX73090

GTX73090 WB Image

Orthogonal

The data was published in the journal Evid Based Complement Alternat Med in 2012. PMID: 23304209

Anti-Caspase 3 antibody used in IHC (Paraffin sections) (IHC-P). GTX73090

GTX73090 IHC-P Image

The data was published in the journal Evid Based Complement Alternat Med in 2012. PMID: 23304209

REFERENCE

Application Reference

MALEK AZIZ et al. Canadian Journal of Physiology and Pharmacology 2019; (Epub) Protective Effects of Olmesartan and L-carnitine on Doxorubicin-Induced Cardiotoxicity in Rats.
Saat N et al. Biotech Histochem 2019; : 1-7 Effect of melatonin on torsion and reperfusion induced pathogenesis of rat uterus.
Application : IHC-P
Reactivity : Rat
Wu KJ et al. Evid Based Complement Alternat Med 2012; 2012 : 656150 Guizhi-Fuling-Wan, a Traditional Chinese Herbal Medicine, Ameliorates Memory Deficits and Neuronal Apoptosis in the Streptozotocin-Induced Hyperglycemic Rodents via the Decrease of Bax/Bcl2 Ratio and Caspase-3 Expression.
Application : IHC
Reactivity : Mouse
F?rat U et al. Exp Diabetes Res 2012; 2012 : 316384 Increased caspase-3 immunoreactivity of erythrocytes in STZ diabetic rats.
Application : IHC
Reactivity : Rat
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SDS
Sodium Azide.pdf
Package List Price ($)
$ 399