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ACTH antibody [AH26]

Anti-ACTH antibody [AH26] used in IHC (Paraffin sections) (IHC-P). GTX73794

Cat No. GTX73794

Host

Mouse

Clonality

Monoclonal

Clone Name

AH26

Isotype

IgG1

Application

IHC-P

Reactivity

Human
Package
1 ml ($539)

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Dilution
IHC-P 1:50‐1:100
Not tested in other applications.

Calculated MW

29 kDa. ( Note )

Specificity/Sensitivity

This antibody is specific to an epitope on the N-terminus of ACTH. This antibody stains corticotrophs in the adenohypophysis and is useful in the classification of pituitary adenomas.

PROPERTIES

Form

Liquid

Buffer

PBS with <0.1% sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC.

Concentration

Batch dependent (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

BALB/C mice were injected with a synthetic peptide corresponding to amino acids 1-24 from the N-terminal of human ACTH.

Purification

Purified IgG

Conjugation

Unconjugated

Note

For laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

TARGET

Synonyms

ACTH , CLIP , LPH , MSH , NPP , POC , POMC , proopiomelanocortin , Corticotropin

Cellular Localization

Secreted

Background

This gene encodes a preproprotein that undergoes extensive, tissue-specific, post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. There are eight potential cleavage sites within the preproprotein and, depending on tissue type and the available convertases, processing may yield as many as ten biologically active peptides involved in diverse cellular functions. The encoded protein is synthesized mainly in corticotroph cells of the anterior pituitary where four cleavage sites are used; adrenocorticotrophin, essential for normal steroidogenesis and the maintenance of normal adrenal weight, and lipotropin beta are the major end products. In other tissues, including the hypothalamus, placenta, and epithelium, all cleavage sites may be used, giving rise to peptides with roles in pain and energy homeostasis, melanocyte stimulation, and immune modulation. These include several distinct melanotropins, lipotropins, and endorphins that are contained within the adrenocorticotrophin and beta-lipotropin peptides. The antimicrobial melanotropin alpha peptide exhibits antibacterial and antifungal activity. Mutations in this gene have been associated with early onset obesity, adrenal insufficiency, and red hair pigmentation. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jan 2016]

Database

Research Area

DATA IMAGES

Anti-ACTH antibody [AH26] used in IHC (Paraffin sections) (IHC-P). GTX73794

GTX73794 IHC-P Image

IHC-P analysis of human pituitary tissue using GTX73794 ACTH antibody [AH26].

REFERENCE

There are currently no references for ACTH antibody [AH26] (GTX73794). Be the first to share your publications with this product.

REVIEW

There are currently no reviews for ACTH antibody [AH26] (GTX73794). Be the first to share your experience with this product.
SDS
PBS.pdf
Sodium Azide.pdf