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Polyclonal Antibodies

Polyclonal Antibodies

Polyclonal antibodies generated by an immunized animal consist of a heterogeneous mix of immunoglobulins derived from many B-cells that individually target distinct epitopes on an antigen. Often representing up to 5% of the total immunoglobulin, these antibodies are generally purified from the immune sera using antigen-affinity chromatography. Polyclonal antibodies are particularly useful for detecting proteins that are expressed at lower levels, and their performance is impacted to a lesser degree by alterations in the antigen (e.g., denaturation). GeneTex offers an extensive catalog of affinity-purified polyclonal antibodies directed against almost all key targets/proteins in the spectrum of biomedical research.

Polyclonal Antibodies

 

Literature
Cardiovascular Research

Pamphlet - Cardiovascular Research

Download the latest version of GeneTex's cardiovascular research pamphlet.
Articles

Five Pillars of Antibody Validation

GeneTex employs various analytic validation strategies to ensure both consistent quality and specificity.
Newsletter
Is ApoE the piece to complete the puzzle of Alzheimer’s disease?

Is ApoE the piece to complete the puzzle of Alzheimer’s disease?

ApoE was identified as a major checkpoint inhibitor of the classical complement cascade, and involved in a possible unifying mechanism underlying Alzheimer’s disease, atherosclerosis, and potentially other inflammatory diseases.
Literature
Circadian Rhythm

Flyer - Circadian Rhythm

Download the latest version of GeneTex's Circadian Rhythm flyer.
Newsletter
Independent Knockout Validation of C9ORF72 Antibodies

Independent Knockout Validation of C9ORF72 Antibodies

Independent Knockout Validation of C9ORF72 Antibodies
Literature
Neurotransmission

Flyer - Neurotransmission

Download the latest version of GeneTex's Neurotransmission flyer.
Literature
Mitochondria

Flyer - Mitochondria

Download the latest version of GeneTex's Mitochondria flyer.
Newsletter
A Well-Cited Nrf2 Antibody for Cellular Redox Research

A Well-Cited Nrf2 Antibody for Cellular Redox Research

Newsletter

Neurodegeneration: A "Vicious Cycle" Involving Mitochondria, Glia, and Neuronal Death

Newsletter

SETD3 Is Pivotal for Infection by Multiple Human Enteroviruses

SETD3 Is Pivotal for Infection by Multiple Human Enteroviruses
Newsletter

Soluble TREM2 is associated with clinical progression of Alzheimer’s disease.

Soluble TREM2 is associated with clinical progression of Alzheimer’s disease.
Newsletter
HBV

Adoptive T cell therapy shows potential to eliminate hepatitis B virus (HBV) infection.

Is a cure for chronic hepatitis B on the horizon? Adoptive T cell therapy shows potential to eliminate hepatitis B virus (HBV) infection.
Newsletter

Dogs Provide Great Help to Human Cancer Research

Dogs Provide Great Help to Human Cancer Research
Newsletter
Online Biology Research Tools

Online Biology Research Tools

GeneTex provides practical online biology research tools.
Newsletter
exosome PD-L1

Improving cancer immunotherapy efficacy may depend on targeting exosomes

Improving cancer immunotherapy efficacy may depend on targeting exosomes bearing the immune checkpoint protein PD-L1
Literature
Recombinant Active Proteins

Flyer - Recombinant Active Proteins

Download the latest version of GeneTex's Recombinant Active Proteins flyer.
Pathways

Autophagy Pathway

Autophagy is the process of self-cannibalization of cellular proteins or organelles through lysosomal degradation.
Pathways

Bcl-2 Pathway

B-cell lymphoma-2 (Bcl-2)-family proteins play an important role in regulating the induction of apoptosis.
Pathways

Notch Pathway

The Notch signaling pathway is an important evolutionarily conserved pathway that plays a vital role in the regulation of asymmetric cell division, cell fate specification, proliferation and apoptosis during development.
Pathways

Apoptosis Pathway

Pathways

Cell Cycle Pathway

Pathways

Histone Code

Pathways

ATM signaling Pathway

It is vital for cells to effectively repair DNA damage and to coordinate DNA repair with cell cycle progression.
Pathways

JAK-STAT Pathway

Pathways

PI3K-Akt-mTOR Pathway

Akt, also known as protein kinase B (PKB) is a serine/threonine kinase that plays an important role in oncogenesis and the cellular processes of metabolism, apoptosis and autophagy.
Pathways

Hypoxia Pathway

Hypoxia in tumors is closely associated with tumor aggressiveness and resistance to radio- and chemotherapeutic treatment.
Pathways

ER Stress Pathway

Literature
Cardiovascular Research

Pamphlet - Cardiovascular Research

Download the latest version of GeneTex's cardiovascular research pamphlet.
Literature
Circadian Rhythm

Flyer - Circadian Rhythm

Download the latest version of GeneTex's Circadian Rhythm flyer.
Literature
Neurotransmission

Flyer - Neurotransmission

Download the latest version of GeneTex's Neurotransmission flyer.
Literature
Mitochondria

Flyer - Mitochondria

Download the latest version of GeneTex's Mitochondria flyer.
Literature
Recombinant Active Proteins

Flyer - Recombinant Active Proteins

Download the latest version of GeneTex's Recombinant Active Proteins flyer.
Literature
World Class Validated Antibodies

Brochure - World Class Validated Antibodies

Download the latest version of GeneTex's World Class Validated Antibodies brochure.
Literature
VetSignal Antibodies

Flyer - VetSignal Antibodies

Download the latest version of GeneTex's VetSignal Antibodies flyer.
Literature
Cancer Signaling

Poster - Cancer Signaling

Download the latest version of GeneTex's cancer signaling poster
Literature

Flyer - Fluorescence Immunostaining

Download the latest version of GeneTex's fluorescence immunostaining flyer.
Literature

Flyer - Five Pillars Validation

Download the latest version of GeneTex's epitope five pillars validation flyer.
Literature

Flyer - Loading Controls

Download the latest version of GeneTex's loading controls flyer.
Literature

Pamphlet - Western Blot Troubleshooting

Download the latest version of GeneTex's pamphlet for western blot troubleshooting.
Literature

Flyer - Upgrade Your Western Blot Results

Download the latest version of GeneTex's flyer for upgrade your western blot results.
Literature

Flyer - IHC Troubleshooting Guide

Download the latest version of GeneTex's IHC troubleshooting guide flyer.
Literature

Poster - Zebrafish

Download the latest version of GeneTex's zebrafish poster.
Literature

Poster - Stem Cell

Download the latest version of GeneTex's stem cell poster.
Literature
Neural Markers

Poster - Neural Markers

Download the latest version of GeneTex's neural markers poster.
Literature

Poster - Immune Response

Download the latest version of GeneTex's immune response poster.
Literature

Flyer - Epitope Tags and Reporters

Download the latest version of GeneTex's epitope tags and reporters flyer.
Literature
Organelle Markers

Poster - Organelle Markers

Download the latest version of GeneTex's organelle markers poster
Literature

Pamphlet - Hot Products

Download the latest version of GeneTex's pamphlet of hot products.
Literature
Epithelial–Mesenchymal Transition

Poster - EMT

Download the latest version of GeneTex's EMT poster
Articles

Five Pillars of Antibody Validation

GeneTex employs various analytic validation strategies to ensure both consistent quality and specificity.
Articles
beta Amyloid

beta Amyloid

GeneTex’s “beta-Amyloid (1-42) antibody – Conformation-Specific” can specifically detect amyloid plaques in the Alzheimer's Disease brain by IHC-P analysis. The superior specificity and sensitivity of this antibody were confirmed by dot blot, ELISA and side-by-side IHC-P comparison with competitor's.
Articles

Approach to Antibody Lot-to-Lot Variability

Lot-to-lot variability is a persistent quality control (QC) issue that contributes to inconsistent results in assays using antibodies.
Articles

Overexpression Antibodies

The validity of a target protein’s endogenous signal can be further substantiated through overexpression of that protein using a recombinant construct.
Articles

Orthogonal_Antibodies

Detecting predicted changes in the antibody-generated signal due to alteration of experimental biological conditions is a reliable approach to gauge antibody performance.
Articles

IP/MS-antibodies

Using mass spectrometry (MS) to identify the protein(s) bound by an antibody is a powerful method for the validation of antibody specificity and performance.
Articles

Knockout/Knockdown Validation

GeneTex is conducting knockout/knockdown-based validation as a fundamental component of its antibody quality assurance process.
Articles

ResponsibleScientists.org

An Open Letter Regarding Climate Change From Concerned Members of the U.S. National Academy of Sciences
Protocols

Protocol - Western Blot

Download GeneTex's Western Blot Protocol.
Protocols

Protocol - ICC/IF

Download GeneTex's ICC/IF Protocol.
Protocols

Protocol - IHC (paraffin)

Download GeneTex's IHC (paraffin) Protocol.
Protocols

Protocol - IHC (frozen)

Download GeneTex's IHC (frozen) Protocol.
Protocols

Protocol - IHC (whole-mount)

Download GeneTex's IHC (whole-mount) Protocol.
Protocols

Protocol - Immunoprecipitation

Download GeneTex's Immunoprecipitation Protocol.
Protocols

Protocol - ELISA (sandwich)

Download GeneTex's ELISA (sandwich) Protocol.
Protocols

Protocol - ELISA (indirect)

Download GeneTex's ELISA (indirect) Protocol.
Protocols

Protocol - Flow Cytometry

Download GeneTex's Flow Cytometry Protocol.
Protocols

Protocol - Dot Blot

Download GeneTex's Dot Blot Protocol.
Protocols

Protocol - Blocking Peptide Competition

Download GeneTex's Blocking Peptide Competition Protocol.
Newsletter
Is ApoE the piece to complete the puzzle of Alzheimer’s disease?

Is ApoE the piece to complete the puzzle of Alzheimer’s disease?

ApoE was identified as a major checkpoint inhibitor of the classical complement cascade, and involved in a possible unifying mechanism underlying Alzheimer’s disease, atherosclerosis, and potentially other inflammatory diseases.
Newsletter
Independent Knockout Validation of C9ORF72 Antibodies

Independent Knockout Validation of C9ORF72 Antibodies

Independent Knockout Validation of C9ORF72 Antibodies
Newsletter
A Well-Cited Nrf2 Antibody for Cellular Redox Research

A Well-Cited Nrf2 Antibody for Cellular Redox Research

Newsletter

Neurodegeneration: A "Vicious Cycle" Involving Mitochondria, Glia, and Neuronal Death

Newsletter

SETD3 Is Pivotal for Infection by Multiple Human Enteroviruses

SETD3 Is Pivotal for Infection by Multiple Human Enteroviruses
Newsletter

Soluble TREM2 is associated with clinical progression of Alzheimer’s disease.

Soluble TREM2 is associated with clinical progression of Alzheimer’s disease.
Newsletter
HBV

Adoptive T cell therapy shows potential to eliminate hepatitis B virus (HBV) infection.

Is a cure for chronic hepatitis B on the horizon? Adoptive T cell therapy shows potential to eliminate hepatitis B virus (HBV) infection.
Newsletter

Dogs Provide Great Help to Human Cancer Research

Dogs Provide Great Help to Human Cancer Research
Newsletter
Online Biology Research Tools

Online Biology Research Tools

GeneTex provides practical online biology research tools.
Newsletter
exosome PD-L1

Improving cancer immunotherapy efficacy may depend on targeting exosomes

Improving cancer immunotherapy efficacy may depend on targeting exosomes bearing the immune checkpoint protein PD-L1